Date published: 2026-5-11

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Sethoxydim (CAS 74051-80-2)

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CAS Number:
74051-80-2
Molecular Weight:
327.48
Molecular Formula:
C17H29NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sethoxydim is an effective herbicide known for its selectivity, systemic nature, and cyclohexanedione oxime composition. It primarily enters plants through their foliage and, to a lesser extent, their roots. By inhibiting the activity of acetyl CoA carboxylase (ACCase), it inhibits the incorporation of acetate into fatty acids, impeding the synthesis of phospholipids essential for membrane formation. This mechanism makes it particularly valuable for controlling annual and perennial grass weeds in a variety of broad-leaved crops.


Sethoxydim (CAS 74051-80-2) References

  1. Inhibition of 4-hydroxyphenylpyruvate dioxygenase by sethoxydim, a potent inhibitor of acetyl-coenzyme A carboxylase.  |  Lin, S. and Yang, D. 1999. Bioorg Med Chem Lett. 9: 551-4. PMID: 10098661
  2. Inhibition of ACCase220 and ACCase240 isozymes from sethoxydim-resistant and -susceptible maize hybrids.  |  Incledon, BJ. and Hall, JC. 1999. J Agric Food Chem. 47: 299-304. PMID: 10563889
  3. Selection and characterization of sethoxydim- tolerant maize tissue cultures.  |  Parker, WB., et al. 1990. Plant Physiol. 92: 1220-5. PMID: 16667393
  4. Effects and Absorption of Sethoxydim in Cell Cycle Progression of Corn (Zea mays) and Pea (Pisum sativum).  |  Hosaka, H. and Takagi, MK. 1992. Plant Physiol. 99: 1650-6. PMID: 16669086
  5. Sethoxydim affects lipid synthesis and acetyl-CoA carboxylase activity in soybean.  |  Belkebir, A., et al. 2006. J Exp Bot. 57: 3553-62. PMID: 16968879
  6. Cellular membranes, the sites for the antifungal activity of the herbicide sethoxydim.  |  Pakdaman, BS., et al. 2007. Pak J Biol Sci. 10: 2480-4. PMID: 19070118
  7. Allelic mutations in acetyl-coenzyme A carboxylase confer herbicide tolerance in maize.  |  Marshall, LC., et al. 1992. Theor Appl Genet. 83: 435-42. PMID: 24202589
  8. Photochemical behavior of sethoxydim in the presence of vegetable oils.  |  Hammami, H., et al. 2014. J Agric Food Chem. 62: 6263-8. PMID: 24932839
  9. Sethoxydim treatment inhibits lipid metabolism and enhances the accumulation of anthocyanins in rape (Brassica napus L.) leaves.  |  Belkebir, A. and Benhassaine-Kesri, G. 2013. Pestic Biochem Physiol. 107: 120-6. PMID: 25149245
  10. Photodegradation behaviour of sethoxydim and its comercial formulation Poast® under environmentally-relevant conditions in aqueous media. Study of photoproducts and their toxicity.  |  Sevilla-Morán, B., et al. 2017. Chemosphere. 168: 501-507. PMID: 27865884
  11. Screening and transcriptomic analysis of Crypthecodinium cohnii mutants with high growth and lipid content using the acetyl-CoA carboxylase inhibitor sethoxydim.  |  Liu, J., et al. 2017. Appl Microbiol Biotechnol. 101: 6179-6191. PMID: 28674851
  12. Inhibition of plant acetyl-coenzyme A carboxylase by the herbicides sethoxydim and haloxyfop.  |  Burton, JD., et al. 1987. Biochem Biophys Res Commun. 148: 1039-44. PMID: 2891354
  13. Transcriptome analysis identified the mechanism of synergy between sethoxydim herbicide and a mycoherbicide on green foxtail.  |  Song, T., et al. 2020. Sci Rep. 10: 21690. PMID: 33303778

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sethoxydim, 10 mg

sc-250974
10 mg
$102.00