Sertindole (CAS 106516-24-9)
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Sertindole is a compound used extensively in neuroscience research, particularly in the study of neurotransmitter systems. It is of interest for its high affinity for dopamine D2, serotonin 5-HT2, and α-adrenoreceptor subtypes, which makes it useful in the investigation of the mechanisms underlying neurotransmission and its modulation. Researchers employ sertindole to explore the role of these receptors in various brain functions and to understand their involvement in neurophysiological pathways. In addition, sertindole is used in studies focusing on receptor binding profiles, which can shed light on signaling pathways and receptor-mediated effects within the central nervous system. The compound is also utilized in electrophysiological experiments to determine the effects of receptor modulation on neuronal firing rates and synaptic transmission, providing insights into the functional consequences of receptor activity.
Sertindole (CAS 106516-24-9) References
- Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. | Idris, N., et al. 2010. Psychopharmacology (Berl). 208: 23-36. PMID: 19851757
- Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice. | Mutlu, O., et al. 2011. Pharmacol Biochem Behav. 99: 557-65. PMID: 21693127
- Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells. | Shin, JH., et al. 2012. Biol Pharm Bull. 35: 1069-75. PMID: 22791154
- Clozapine, ziprasidone, and sertindole-induced morphological changes in the rat heart and their relationship to antioxidant enzymes function. | Nikolić-Kokić, A., et al. 2018. J Toxicol Environ Health A. 81: 844-853. PMID: 30036154
- Photodegradation Study of Sertindole by UHPLC-ESI-Q-TOF and Influence of Some Metal Oxide Excipients on the Degradation Process. | Trawiński, J. and Skibiński, R. 2019. Pharmaceutics. 11: PMID: 31252531
- Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles. | Yoon, YS., et al. 2020. BMB Rep. 53: 166-171. PMID: 31964466
- Effects of several atypical antipsychotics closapine, sertindole or ziprasidone on hepatic antioxidant enzymes: Possible role in drug-induced liver dysfunction. | Platanić Arizanović, L., et al. 2021. J Toxicol Environ Health A. 84: 173-182. PMID: 33234086
- Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats. | Nawwar, DA., et al. 2022. Inflammopharmacology. 30: 1891-1907. PMID: 35876932
- Antibacterial and Antibiofilm Activities of Sertindole and Its Antibacterial Mechanism against Staphylococcus aureus. | Tang, Y., et al. 2023. ACS Omega. 8: 5415-5425. PMID: 36816695
- Effects of sertindole on sleep-wake states, electroencephalogram, behavioral patterns, and epileptic activity of rats. | Coenen, AM., et al. 1995. Pharmacol Biochem Behav. 51: 353-7. PMID: 7667352
- Sertindole antagonizes morphine-, cocaine-, and methamphetamine-induced place preference in the rat. | Suzuki, T. and Misawa, M. 1995. Life Sci. 57: 1277-84. PMID: 7674819
- Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism. | Sakamoto, K., et al. 1995. Xenobiotica. 25: 1327-43. PMID: 8719908
- Pharmacokinetics of sertindole and dehydrosertindole in volunteers with normal or impaired renal function. | Wong, SL., et al. 1997. Eur J Clin Pharmacol. 52: 223-7. PMID: 9218930
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sertindole, 10 mg | sc-215846 | 10 mg | $240.00 | |||
Sertindole, 50 mg | sc-215846A | 50 mg | $850.00 |