SerpinA3g Antibody (MoFo29.2): sc-57013

SerpinA3g Antibody (MoFo29.2) is a hamster monoclonal IgG antibody that detects SerpinA3g protein of mouse origin by western blotting (WB) and immunoprecipitation (IP). Anti-SerpinA3g antibody (MoFo29.2) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. SerpinA3g, also known as Spi2A, plays a crucial role in regulating various biological processes, including immune responses and inflammation. This serine proteinase inhibitor is primarily located in the nucleus, where SerpinA3g is expressed at high levels in hematopoietic progenitors and is down-regulated during differentiation. SerpinA3g′s unique structure includes an unusual reactive site Cys-Cys sequence and a distinctive C-terminal extension, which contribute to functional versatility. Notably, SerpinA3g is dramatically up-regulated upon T-cell activation and in macrophages during infections with pathogens such as Salmonella typhimurium and Listeria monocytogenes. SerpinA3g is activated by interferon-gamma and nuclear factor kappa B, suggesting involvement in mediating biological effects through interactions with non-protease intracellular targets. SerpinA3g (MoFo29.2) antibody enables researchers to gain valuable insights into SerpinA3g′s role in immune regulation and potential implications in disease processes.

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SerpinA3g Antibody (MoFo29.2) References:

1. Serpin 2a is induced in activated macrophages and conjugates to a ubiquitin homolog.  |  Hamerman, JA., et al. 2002. J Immunol. 168: 2415-23. PMID: 11859133
2. A minimal serpin promoter with high activity in haematopoietic progenitors and activated T cells.  |  Hampson, L., et al. 2001. Hematol J. 2: 150-60. PMID: 11920240
3. Murine serpin 2A is a redox-sensitive intracellular protein.  |  Morris, EC., et al. 2003. Biochem J. 371: 165-73. PMID: 12470299
4. Serpin structure, mechanism, and function.  |  Gettins, PG. 2002. Chem Rev. 102: 4751-804. PMID: 12475206
5. BmSPN2, a serpin secreted by the filarial nematode Brugia malayi, does not inhibit human neutrophil proteinases but plays a noninhibitory role.  |  Stanley, P. and Stein, PE. 2003. Biochemistry. 42: 6241-8. PMID: 12755628
6. Serpins: structure, function and molecular evolution.  |  van Gent, D., et al. 2003. Int J Biochem Cell Biol. 35: 1536-47. PMID: 12824063
7. How serpins change their fold for better and for worse.  |  Carrell, RW. and Huntington, JA. 2003. Biochem Soc Symp. 163-78. PMID: 14587291
8. Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.  |  Silverman, GA., et al. 2004. Cell Mol Life Sci. 61: 301-25. PMID: 14770295
9. Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells.  |  Hampson, IN., et al. 1997. Blood. 89: 108-18. PMID: 8978283

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SerpinA3g Antibody (MoFo29.2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SerpinA3g Antibody (MoFo29.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SerpinA3g Antibody (MoFo29.2) Specifications

Alternate Product Name: SerpinA3g

Product Clone Name: MoFo29.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids: 418-436

Epitope Target: SerpinA3g

Epitope Species: mouse

Product Reactivity/Detection: SerpinA3g

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SerpinA3g Antibody (MoFo29.2): N/A