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Serotonin-d4 hydrochloride (CAS 50-67-9 (unlabeled))

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Alternate Names:
3-(2-Aminoethyl-d4)-1H-indol-5-ol Hydrochloride; 5-Hydroxytryptamine-d4 Hydrochloride; Hippophaine-d4 Hydrochloride
Application:
Serotonin-d4 hydrochloride is a deuterated serotonin compound
CAS Number:
50-67-9 (unlabeled)
Molecular Weight:
216.68
Molecular Formula:
C10H8D4N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Serotonin-d4 hydrochloride is the deuterium-labeled form of serotonin (sc-201146A), a monoamine neurotransmitter. It helps regulate mood, sleep, memory, appetite, and other functions. It is employed as a tracer in neurochemistry and neuroscience studies to investigate various aspects of serotonin neurotransmission. Specifically, it is used in positron emission tomography (PET) or autoradiography experiments that contribute to understanding the role of serotonin in various physiological and pathological processes, including mood regulation, cognition, and psychiatric disorders.


Serotonin-d4 hydrochloride (CAS 50-67-9 (unlabeled)) References

  1. Quantification of neurotransmitters in mouse brain tissue by using liquid chromatography coupled electrospray tandem mass spectrometry.  |  Kim, TH., et al. 2014. J Anal Methods Chem. 2014: 506870. PMID: 25258696
  2. Determination of monoamine neurotransmitters in zebrafish (Danio rerio) by gas chromatography coupled to mass spectrometry with a two-step derivatization.  |  Aragon, A., et al. 2017. Anal Bioanal Chem. 409: 2931-2939. PMID: 28204887
  3. Development and validation of a liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of serotonin and thromboxane B2 from activated platelets.  |  Minet, V., et al. 2018. Int J Lab Hematol. 40: 663-671. PMID: 30019376
  4. Analysis of Tryptophan Metabolites in Serum Using Wide-Isolation Strategies for UHPLC-HRMS/MS.  |  Rubio, VY., et al. 2020. Anal Chem. 92: 2550-2557. PMID: 31927994
  5. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis.  |  Engevik, MA., et al. 2021. Cell Mol Gastroenterol Hepatol. 11: 221-248. PMID: 32795610
  6. Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice.  |  Fields, AM., et al. 2021. Commun Biol. 4: 421. PMID: 33772108
  7. Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice.  |  Kim, K., et al. 2021. Am J Physiol Renal Physiol. 321: F106-F119. PMID: 34121452
  8. Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring.  |  Wang, B., et al. 2022. Sci Adv. 8: eabk0967. PMID: 34985954
  9. Identification and Characterization of Auxin/IAA Biosynthesis Pathway in the Rice Blast Fungus Magnaporthe oryzae.  |  Dong, L., et al. 2022. J Fungi (Basel). 8: PMID: 35205962
  10. LC-MS/MS determination of GTS-201, a dipeptide mimetic of the brain-derived neurotrophic factor, and neurotransmitter metabolites with application to a pharmacokinetic study in rats.  |  Markin, PA., et al. 2023. J Pharm Biomed Anal. 223: 115125. PMID: 36375394
  11. Detection of Changes in Monoamine Neurotransmitters by the Neonicotinoid Pesticide Imidacloprid Using Mass Spectrometry.  |  Hirai, A., et al. 2022. Toxics. 10: PMID: 36422903
  12. The Lignan-Rich Fraction from Sambucus williamsii Hance Exerts Bone Protective Effects via Altering Circulating Serotonin and Gut Microbiota in Rats.  |  Xiao, HH., et al. 2022. Nutrients. 14: PMID: 36432403
  13. Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders.  |  Janus, T., et al. 2022. Stem Cell Rev Rep.. PMID: 36577910
  14. Characteristics of tissue distribution, metabolism, effects on brain catecholamines, and environmental exposure of frogs to neonicotinoid insecticides.  |  Shinya, S., et al. 2023. Aquat Toxicol. 257: 106437. PMID: 36827829

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Serotonin-d4 hydrochloride, 2.5 mg

sc-473411
2.5 mg
$355.00

Serotonin-d4 hydrochloride, 25 mg

sc-473411A
25 mg
$2448.00

Is this soluble in DMSO?

Asked by: chemicalsmg
Thank you for your question. Serotonin-d4 hydrochloride: sc-473411 is slightly soluble in DMSO.
Answered by: Chemical Support 3
Date published: 2017-03-10

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. Serotonin-d4 hydrochloride: sc-473411is expected to be a brownish grey to light greyish purple solid.
Answered by: Chemical Support 3
Date published: 2017-03-10
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Rated 5 out of 5 by from Used as an internal standard for LC-MSWorked perfectly as an internal standard for LC-MS
Date published: 2017-09-15
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Serotonin-d4 hydrochloride is rated 5.0 out of 5 by 1.
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