Serotonin β-D-Glucuronide (CAS 18186-43-1)
Alternate Names:
3-(2-Aminoethyl)-1H-indol-5-yl β-D-Glucopyranosiduronic acid; 5-Hydroxytryptamine O-Glucuronide; 5-Hydroxytryptamine Glucuronide
CAS Number:
18186-43-1
Molecular Weight:
352.34
Molecular Formula:
C16H20N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Serotonin β-D-Glucuronide is a metabolite of serotonin, a neurotransmitter involved in the regulation of mood, appetite, and sleep. This conjugation reaction is catalyzed by the enzyme UDP-glucuronosyltransferase. It is involved in the detoxification of serotonin and other related compounds. The glucuronidation of serotonin is an important pathway for the metabolism of this neurotransmitter.
Serotonin β-D-Glucuronide (CAS 18186-43-1) References
- Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin. | Lee, SY., et al. 2015. Toxicol Lett. 235: 107-15. PMID: 25835148
- Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. | Kutsuno, Y., et al. 2015. Drug Metab Dispos. 43: 1071-6. PMID: 25953521
- Species and tissue differences in serotonin glucuronidation. | Sakakibara, Y., et al. 2016. Xenobiotica. 46: 605-611. PMID: 26526550
- Single-shot multi-reaction monitoring of intact marker conjugates for quantitative profiling of human major microsomal glucuronidations and its utility to screen inhibitors from medicinal herbs. | Cheng, Y., et al. 2016. Anal Bioanal Chem. 408: 8117-8132. PMID: 27604270
- Characterization of β-Estradiol 3-Glucuronidation in Rat Brain. | Asai, Y., et al. 2017. Biol Pharm Bull. 40: 1556-1560. PMID: 28867738
- Effect of carbamazepine on expression of UDP-glucuronosyltransferase 1A6 and 1A7 in rat brain. | Asai, Y., et al. 2017. Drug Metab Pharmacokinet. 32: 286-292. PMID: 29158009
- Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes. | Chen, A., et al. 2018. Toxicol Lett. 295: 379-389. PMID: 30036684
- Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach. | Cheng, Y., et al. 2019. Toxicol Lett. 312: 214-221. PMID: 31128210
- Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. | Luo, H., et al. 2020. Regul Toxicol Pharmacol. 113: 104637. PMID: 32145316
- Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin. | Walsh, J., et al. 2020. Am J Physiol Gastrointest Liver Physiol. 318: G816-G826. PMID: 32146834
- Industrial Approach to Determine the Relative Contribution of Seven Major UGT Isoforms to Hepatic Glucuronidation. | Busse, D., et al. 2020. J Pharm Sci. 109: 2309-2320. PMID: 32294459
- The gut microbiome influences the bioavailability of olanzapine in rats. | Cussotto, S., et al. 2021. EBioMedicine. 66: 103307. PMID: 33819741
- The Effect of Single-Walled Carbon Nanotubes on UDP-Glucuronosyltransferase 1A Activity in Human Liver. | Asai, Y., et al. 2022. Biol Pharm Bull. 45: 446-451. PMID: 35370268
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Serotonin β-D-Glucuronide, 5 mg | sc-472673 | 5 mg | $398.00 |