Molecular structure of Seratrodast, CAS Number: 112665-43-7
Seratrodast (CAS 112665-43-7)
Application:
Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist
CAS Number:
112665-43-7
Purity:
≥99%
Molecular Weight:
354.44
Molecular Formula:
C22H26O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Seratrodast, also known as AA-2414, is a potent and selective antagonist of the thromboxane A2 receptor. Seratrodast is described to produce antioxidant effects, and is demonstrated to inhibit peroxide-induced vasoconstriction in human placenta. Additionally, it inhibit bronchoconstriction in guinea pigs in response to leukotriene D4, U-46619, and platelet activating factor.
Seratrodast (CAS 112665-43-7) References
- AA-2414, an antioxidant and thromboxane receptor blocker, completely inhibits peroxide-induced vasoconstriction in the human placenta. | Walsh, SW., et al. 1999. J Pharmacol Exp Ther. 290: 220-6. PMID: 10381779
- Antagonism of the TXA2 receptor by seratrodast: a structural approach. | Wouters, J., et al. 1999. Bioorg Med Chem Lett. 9: 2867-70. PMID: 10522708
- Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. | Cui, S., et al. 2007. Eur J Pharmacol. 576: 99-106. PMID: 17706964
- Isolation and structure elucidation of the major photodegradation products of seratrodast. | Xu, J., et al. 2008. J Pharm Biomed Anal. 48: 78-84. PMID: 18562149
- Two pharmacological phases in antigen-induced immediate airway response in rats. | Miyagawa, N., et al. 2008. Biol Pharm Bull. 31: 2260-4. PMID: 19043210
- Blocking of thromboxane A₂ receptor attenuates airway mucus hyperproduction induced by cigarette smoke. | An, J., et al. 2013. Eur J Pharmacol. 703: 11-7. PMID: 23399768
- A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | Ashida, Y., et al. 1989. Prostaglandins. 38: 91-112. PMID: 2748922
- Investigating the possible mechanisms involved in adenosine preconditioning-induced cardioprotection in rats. | Singh, L., et al. 2018. Cardiovasc Ther. 36: e12328. PMID: 29604187
- Regulation of liver regeneration by prostaglandin E2 and thromboxane A2 following partial hepatectomy in rats. | Mohamed, YS., et al. 2020. Naunyn Schmiedebergs Arch Pharmacol. 393: 1437-1446. PMID: 32162076
- Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. | Hao, Y., et al. 2022. Brain Res. 1795: 148073. PMID: 36075466
- Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. | Kurokawa, T., et al. 1994. Biol Pharm Bull. 17: 383-5. PMID: 8019502
- Characterization of the pharmacokinetics and pharmacodynamics of a new oral thromboxane A2-receptor antagonist AA-2414 in normal subjects: population analysis. | Hussein, Z., et al. 1994. Clin Pharmacol Ther. 55: 441-50. PMID: 8162671
- Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001). | Kumar, GN., et al. 1997. Drug Metab Dispos. 25: 110-5. PMID: 9010637
Inhibitor of:
PAF Acetylhydrolase, and TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Seratrodast, 10 mg | sc-201352 | 10 mg | $68.00 | |||
Seratrodast, 50 mg | sc-201352A | 50 mg | $380.00 |