Septin 9 Antibody (2C6): sc-293291
- Septin 9 Antibody (2C6) is a mouse monoclonal IgG2a κ Septin 9 antibody, cited in 3 publications, provided at 100 µg/ml
- raised against amino acids 26-125 of Septin 9 of human origin
- recommended for detection of Septin 9 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Septin 9 Antibody (2C6). This work is in progress.
Septin 9 Antibody (2C6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Septin 9 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Septin 9 antibody (2C6) is available as a non-conjugated format. Septin 9 is a crucial member of the septin family, consisting of cytoskeletal GTPases that play a significant role in various cellular processes. Septin 9 is involved in forming higher-order filamentous structures that serve as dynamic scaffolds for other proteins, influencing cellular architecture and function. Expression is particularly prominent in lymphoid tissues, with 15 different isoforms generated through the combination of five alternate amino termini and three alternate carboxy termini. This diversity allows for a range of functional roles within the cell, but alterations in isoform expression levels can lead to disruptions in cellular behavior, potentially contributing to conditions such as neoplasia. Septin 9 has been found to be upregulated in ovarian tumors and is associated with hereditary neuralgic amyotrophy, a recurrent neuropathy affecting the brachial plexus. Septin 9′s ability to interact with various proteins underscores its importance in cellular signaling and structural integrity, making anti-Septin 9 antibody (2C6) a valuable tool for researchers studying its role in health and disease.
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Septin 9 Antibody (2C6) References:
- Altered expression of the septin gene, SEPT9, in ovarian neoplasia. | Burrows, JF., et al. 2003. J Pathol. 201: 581-8. PMID: 14648661
- Properties of SEPT9 isoforms and the requirement for GTP binding. | Robertson, C., et al. 2004. J Pathol. 203: 519-27. PMID: 15095474
- Analysis of mammalian septin expression in human malignant brain tumors. | Kim, DS., et al. 2004. Neoplasia. 6: 168-78. PMID: 15140406
- Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. | Nagata, K., et al. 2004. J Biol Chem. 279: 55895-904. PMID: 15485874
- Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours. | Scott, M., et al. 2005. Oncogene. 24: 4688-700. PMID: 15782116
- SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity. | Chacko, AD., et al. 2005. J Pathol. 206: 458-65. PMID: 15902694
- Expression profiling the human septin gene family. | Hall, PA., et al. 2005. J Pathol. 206: 269-78. PMID: 15915442
- Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis. | Scott, M., et al. 2006. Int J Cancer. 118: 1325-9. PMID: 16161048
- Mutations in SEPT9 cause hereditary neuralgic amyotrophy. | Kuhlenbäumer, G., et al. 2005. Nat Genet. 37: 1044-6. PMID: 16186812
- Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets. | Song, PX., et al. 2022. iScience. 25: 104288. PMID: 35573204
- Septin 9 methylation analysis of lymph node micrometastases for predicting relapse of colorectal cancer. | Wan, Y., et al. 2022. Ann Diagn Pathol. 60: 152021. PMID: 35939880
- Septin 9 controls CCNB1 stabilization via APC/CCDC20 during meiotic metaphase I/anaphase I transition in mouse oocytes. | Chen, L., et al. 2023. Cell Prolif. 56: e13359. PMID: 36354207
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Septin 9 Antibody (2C6) | sc-293291 | 100 µg/ml | $322.00 |