Senegenin (CAS 2469-34-3)
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Senegenin is a compound that functions as a saponin, which is known for its ability to interact with cholesterol and other lipids in cell membranes. It acts by disrupting the structure and function of the lipid bilayer, leading to changes in membrane permeability and fluidity. This disruption can affect the activity of membrane-bound proteins and ion channels, ultimately influencing cellular processes such as signal transduction and transport. Senegenin′s mode of action involves its ability to target and interact with cholesterol molecules within the membrane, leading to alterations in membrane properties. Senegenin has been studied for its effects on membrane structure and function, providing insights into the role of saponins in modulating cellular processes. Its interactions at the molecular level have been of interest in understanding the impact of saponins on lipid bilayers and membrane-associated proteins.
Senegenin (CAS 2469-34-3) References
- Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats. | Xie, W., et al. 2012. PLoS One. 7: e45575. PMID: 23029109
- [Neurotrophic effects of senegenin]. | Pi, T., et al. 2013. Zhong Yao Cai. 36: 1477-80. PMID: 24620696
- Protective effect of senegenin on splenectomy-induced postoperative cognitive dysfunction in elderly rats. | Yu, L., et al. 2014. Exp Ther Med. 7: 821-826. PMID: 24660030
- Senegenin Inhibits Hypoxia/Reoxygenation-Induced Neuronal Apoptosis by Upregulating RhoGDIα. | Li, X., et al. 2015. Mol Neurobiol. 52: 1561-1571. PMID: 25367882
- PI3K/Akt signaling pathway is involved in the neurotrophic effect of senegenin. | Pi, T., et al. 2016. Mol Med Rep. 13: 1257-62. PMID: 26647727
- Effects of Senegenin against hypoxia/reoxygenation-induced injury in PC12 cells. | Zhu, XQ., et al. 2016. Chin J Integr Med. 22: 353-61. PMID: 26759162
- Senegenin Ameliorate Acute Lung Injury Through Reduction of Oxidative Stress and Inhibition of Inflammation in Cecal Ligation and Puncture-Induced Sepsis Rats. | Liu, CH., et al. 2016. Inflammation. 39: 900-6. PMID: 26945584
- Senegenin inhibits neuronal apoptosis after spinal cord contusion injury. | Zhang, SQ., et al. 2016. Neural Regen Res. 11: 657-63. PMID: 27212931
- Senegenin Inhibits Aβ1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via Activation of the PI3K/Akt Signaling Pathway. | Ren, X., et al. 2022. Neuropsychiatr Dis Treat. 18: 513-524. PMID: 35280979
- Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics. | Shen, X., et al. 2022. Int J Anal Chem. 2022: 3401355. PMID: 35432545
- Senegenin alleviates Aβ1-42 induced cell damage through triggering mitophagy. | Tian, Y., et al. 2022. J Ethnopharmacol. 295: 115409. PMID: 35640739
- Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia. | Chen, Z., et al. 2022. Front Pharmacol. 13: 937333. PMID: 35924058
- Senegenin Rescues PC12 Cells with Oxidative Damage Through Inhibition of Ferroptosis. | Zhang, H., et al. 2022. Mol Neurobiol. 59: 6983-6992. PMID: 36068400
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Senegenin, 5 mg | sc-483528 | 5 mg | $82.00 |