Molecular structure of Sematilide monohydrochloride monohydrate, CAS Number: 101526-62-9 (non-salt)
Sematilide monohydrochloride monohydrate (CAS 101526-62-9 (non-salt))
CAS Number:
101526-62-9 (non-salt)
Molecular Weight:
367.89
Molecular Formula:
C14H23N3O3S·HCl•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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A class III antiarrhythmic compound showing selective delayed rectifier K+ current channel blocking. It has been shown to inhibit rapidly activating lk in atrial myocytes in guinea pigs. This results in the prolongation of AP duration and refractor capacity. Has exhibited proarrhythmic effects, potentailly leading to QT interval prolongation.
Sematilide monohydrochloride monohydrate (CAS 101526-62-9 (non-salt)) References
1. Yoshida, H., et al, Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model Circ. J. 66, 758-762 2. Ishii, Y., et al., Effects of sematilide, a novel class III antiarrhythmic agent, on delayed rectifier K+ current in guinea pig atrial myocytes Jpn. J. Pharmacol. 71, 361-365, (1996)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sematilide monohydrochloride monohydrate, 50 mg | sc-253550 | 50 mg | $395.00 |