SEMA6C Antibody (Ex-14): sc-74277
- SEMA6C Antibody (Ex-14) is a rat monoclonal IgG2a SEMA6C antibody provided at 100 µg/ml
- raised against an extracellular domain of SEMA6C of mouse origin
- recommended for detection of SEMA6C of mouse, rat and human origin by WB, IF and IHC(P); non cross-reactive with SEMA3B, SEMA3C, SEMA3E, SEMA3F, SEMA6A, SEMA6D or SEMA7A of mouse origin or SEMA3A or SEMA6B of human origin
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SEMA6C Antibody (Ex-14). This work is in progress.
SEMA6C Antibody (Ex-14) is a rat monoclonal IgG2a antibody that detects SEMA6C protein of mouse, rat, and human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-SEMA6C antibody (Ex-14) is available as a non-conjugated format, targeting a crucial member of the semaphorin family, which plays a significant role in neural development and cellular signaling. SEMA6C protein is a transmembrane protein predominantly expressed in fetal brain and adult skeletal muscle, and exists in three isoforms due to alternative splicing: SEMA6C 1, SEMA6C 2, and SEMA6C 3. The extracellular domain of SEMA6C induces growth cone collapse in dorsal root ganglion neurons, which is essential for proper neuronal guidance and synaptic stability. This function is vital for the generation and maintenance of entorhino-hippocampal synapses, highlighting SEMA6C′s role in neurodevelopmental processes and potential implications in neurological disorders. With a well-characterized structure, including a conserved semaphorin domain and additional transmembrane and cytoplasmic regions, SEMA6C monoclonal antibody (Ex-14) serves as a valuable tool for researchers investigating the intricate mechanisms of neural development and synaptic plasticity.
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SEMA6C Antibody (Ex-14) References:
- Cloning and characterization of a novel class VI semaphorin, semaphorin Y. | Kikuchi, K., et al. 1999. Mol Cell Neurosci. 13: 9-23. PMID: 10049528
- Identification, characterization, and functional study of the two novel human members of the semaphorin gene family. | Qu, X., et al. 2002. J Biol Chem. 277: 35574-85. PMID: 12110693
- A role for semaphorins and neuropilins in oligodendrocyte guidance. | Cohen, RI., et al. 2003. J Neurochem. 85: 1262-78. PMID: 12753085
- Cocaine-induced expression changes of axon guidance molecules in the adult rat brain. | Bahi, A. and Dreyer, JL. 2005. Mol Cell Neurosci. 28: 275-91. PMID: 15691709
- An initial blueprint for myogenic differentiation. | Blais, A., et al. 2005. Genes Dev. 19: 553-69. PMID: 15706034
- Semaphorin 6C leads to GSK-3-dependent growth cone collapse and redistributes after entorhino-hippocampal axotomy. | Burgaya, F., et al. 2006. Mol Cell Neurosci. 33: 321-34. PMID: 17029982
- Axon guidance in the spinal cord: choosin' by exclusion. | Frank, E. 2006. Neuron. 52: 745-6. PMID: 17145495
- PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. | Yoshida, Y., et al. 2006. Neuron. 52: 775-88. PMID: 17145500
- Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. | Katoh, M. and Katoh, M. 2007. Int J Mol Med. 20: 405-9. PMID: 17671748
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEMA6C Antibody (Ex-14) | sc-74277 | 100 µg/ml | $316.00 |