SEMA6B Antibody (XX09-t): sc-74276
- SEMA6B Antibody (XX09-t) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against an extracellular domain of SEMA6B of human origin
- recommended for detection of SEMA6B of mouse, rat and human origin by WB; non cross-reactive with SEMA3A, SEMA3B, SEMA6A, SEMA6C, SEMA6D or SEMA7A of human origin or SEMA3C, SEMA3E or SEMA3F of mouse origin
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SEMA6B Antibody (XX09-t). This work is in progress.
SEMA6B Antibody (XX09-t) is a mouse monoclonal IgG1 antibody that detects SEMA6B in mouse, rat, and human samples through western blotting (WB). SEMA6B, also known as SEMA Z, is a single-pass type-I transmembrane protein that plays a crucial role in neural development and is predominantly expressed in the adult brain and heart. SEMA6B is characterized by a proline-rich cytoplasmic domain that contains binding sites for SH3 domains, which are essential for protein-protein interactions. The structure of SEMA6B allows for function as a repellent for sympathetic ganglion axons, effectively suppressing neurite outgrowth and influencing neuronal connectivity. This repellent activity is mediated through interaction with the receptor plexin-A4, highlighting SEMA6B′s importance in guiding neural development. Emerging research suggests SEMA6B may have implications in tumor progression, making anti-SEMA6B antibody (XX09-t) an invaluable tool for researchers investigating the complex roles of semaphorins in both developmental biology and cancer research.
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SEMA6B Antibody (XX09-t) References:
- Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development. | Matsuoka, RL., et al. 2013. PLoS One. 8: e63207. PMID: 23646199
- Analysis of SEMA6B gene expression in breast cancer: identification of a new isoform. | D'Apice, L., et al. 2013. Biochim Biophys Acta. 1830: 4543-53. PMID: 23665584
- De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. | Hamanaka, K., et al. 2020. Am J Hum Genet. 106: 549-558. PMID: 32169168
- Novel Truncating and Missense Variants in SEMA6B in Patients With Early-Onset Epilepsy. | Xiaozhen, S., et al. 2021. Front Cell Dev Biol. 9: 633819. PMID: 34017830
- A De Novo SEMA6B Variant in a Chinese Patient with Progressive Myoclonic Epilepsy-11 and Review of the Literature. | Li, Q., et al. 2021. J Mol Neurosci. 71: 1944-1950. PMID: 34218423
- SEMA6B Overexpression Predicts Poor Prognosis and Correlates With the Tumor Immunosuppressive Microenvironment in Colorectal Cancer. | Li, T., et al. 2021. Front Mol Biosci. 8: 687319. PMID: 34938771
- SEMA6B variants cause intellectual disability and alter dendritic spine density and axon guidance. | Cordovado, A., et al. 2022. Hum Mol Genet. 31: 3325-3340. PMID: 35604360
- Progressive myoclonus epilepsies due to SEMA6B mutations. New variants and appraisal of published phenotypes. | Castellotti, B., et al. 2023. Epilepsia Open. 8: 645-650. PMID: 36719163
- Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy. | Hong, K., et al. 2023. Front Immunol. 14: 1128390. PMID: 36761753
- SEMA6B induces macrophage-mediated inflammation and hepatocyte apoptosis in hepatitis B virus-related acute-on-chronic liver failure. | Yang, H., et al. 2024. Theranostics. 14: 5200-5218. PMID: 39267780
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEMA6B Antibody (XX09-t) | sc-74276 | 100 µg/ml | $322.00 |