Molecular structure of Securinine, CAS Number: 5610-40-2
Securinine (CAS 5610-40-2)
See product citations (3)
Alternate Names:
Virosecurinine; (−)-Securinine
Application:
Securinine is a GABA receptor antagonist
CAS Number:
5610-40-2
Molecular Weight:
217.26
Molecular Formula:
C13H15NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Securinine is an alkaloid naturally occurring in the Securinega plant genus. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist. In vitro studies have been undertaken to assess its impact on cell cultures. Although the precise mechanism of action of securinine remains incompletely understood, it is believed to exert its effects through the inhibition of enzymes involved in cell proliferation and differentiation.
Securinine (CAS 5610-40-2) References
- Securinine induced apoptosis in human leukemia HL-60 cells. | Dong, NZ., et al. 1999. Zhongguo Yao Li Xue Bao. 20: 267-70. PMID: 10452105
- Some toxicologic properties of the alkaloids galanthamine and securinine. | FRIESS, SL., et al. 1961. Toxicol Appl Pharmacol. 3: 347-57. PMID: 13702084
- A new general access to either type of Securinega alkaloids: synthesis of securinine and (-)-allonorsecurinine. | Alibés, R., et al. 2004. Org Lett. 6: 1813-6. PMID: 15151421
- Enantioselective approach to Securinega alkaloids. Total synthesis of securinine and (-)-norsecurinine. | González-Gálvez, D., et al. 2009. J Org Chem. 74: 6199-211. PMID: 19627163
- Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells. | Rana, S., et al. 2010. FASEB J. 24: 2126-34. PMID: 20133503
- Securinine, a myeloid differentiation agent with therapeutic potential for AML. | Gupta, K., et al. 2011. PLoS One. 6: e21203. PMID: 21731671
- Antifungal Activity of Securinine against Some Plant Pathogenic Fungi. | Singh, AK., et al. 2008. Mycobiology. 36: 99-101. PMID: 23990741
- Neuroprotective Effects of the Securinine-Analogues: Identification of Allomargaritarine as a Lead Compound. | Neganova, ME., et al. 2016. CNS Neurol Disord Drug Targets. 15: 102-7. PMID: 26295814
- Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities. | Tang, G., et al. 2016. ACS Chem Neurosci. 7: 1442-1451. PMID: 27467236
- Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase. | Zhang, J., et al. 2017. Biochim Biophys Acta Mol Basis Dis. 1863: 129-138. PMID: 27777067
- Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease. | Leonoudakis, D., et al. 2017. Mediators Inflamm. 2017: 8302636. PMID: 28473732
- Securinine alkaloids: a new class of GABA receptor antagonist. | Beutler, JA., et al. 1985. Brain Res. 330: 135-40. PMID: 2985189
- Securinine Induces Differentiation of Human Promyelocytic Leukemic HL-60 Cells through JNK-Mediated Signaling Pathway. | Sharma, J., et al. 2022. Nutr Cancer. 74: 1122-1137. PMID: 33998358
- Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs. | Klochkov, S. and Neganova, M. 2021. RSC Adv. 11: 19185-19195. PMID: 35478659
- Potential anticancer activities of securinine and its molecular targets. | Liu, CJ., et al. 2022. Phytomedicine. 106: 154417. PMID: 36063584
Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Securinine, 50 mg | sc-220097 | 50 mg | $270.00 | |||
Securinine, 100 mg | sc-220097A | 100 mg | $418.00 |