SDZ WAG 994 is a selective and potent Adenosine A1-R agonist (Ki values are 23, > 10000 and 25000 nM for Adenosine A1-R, Adenosine A2A-R and Adenosine A2B-R, respectively). SDZ WAG 994 inhibits adenosine deaminase-stimulated lipolysis in adipocytes (Ki = 8 nM).
Wagner et al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34 276. Ishikawa et al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3. Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247.
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