SDZ WAG 994 CAS: 130714-47-5
MF: C17H25N5O4
MW: 363.41
A selective Adenosine A1-R agonist.

SDZ WAG 994 (CAS 130714-47-5)

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Alternate Names: N-Cyclohexyl-2'-O-methyladenosine
Application: SDZ WAG 994 is a selective Adenosine A1-R agonist
CAS Number: 130714-47-5
Molecular Weight: 363.41
Molecular Formula: C17H25N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SDZ WAG 994 is a selective and potent Adenosine A1-R agonist (Ki values are 23, > 10000 and 25000 nM for Adenosine A1-R, Adenosine A2A-R and Adenosine A2B-R, respectively). SDZ WAG 994 inhibits adenosine deaminase-stimulated lipolysis in adipocytes (Ki = 8 nM).


References

Wagner et al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34 276. Ishikawa et al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3. Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247.

Physical State :
Solid
Solubility :
Soluble to 100 mM in 1.1 eq. NaOH and to 100 mM in DMSO
Storage :
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
164305
SMILES :
COC1C(C(OC1N2C=NC3=C2N=CN=C3NC4CCCCC4)CO)O

Download SDS (MSDS)

Certificate of Analysis

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