SDF-4 Antibody (E-12): sc-393930

SDF-4 Antibody (E-12) is a mouse monoclonal IgM antibody that detects SDF-4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SDF-4 antibody (E-12) is available as the non-conjugated monoclonal isotype antibody. SDF-4, also known as Cab45, plays a crucial role in cellular signaling and is characterized by six EF-hand calcium-binding motifs, which are essential for calcium-dependent processes. SDF-4 is predominantly localized in the Golgi apparatus, where SDF-4 regulates various calcium-dependent activities, influencing cellular responses to external stimuli. SDF-4′s ability to modulate calcium signaling is particularly important in immune responses, affecting migration and activation of immune cells. With widespread expression and functional significance, SDF-4 serves as a key player in the chemokine network, contributing to immune cell trafficking and activation in various physiological and pathological contexts.

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SDF-4 Antibody (E-12) References:

1. Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8.  |  Laterveer, L., et al. 1996. Blood. 87: 781-8. PMID: 8555503
2. Cab45, a novel (Ca2+)-binding protein localized to the Golgi lumen.  |  Scherer, PE., et al. 1996. J Cell Biol. 133: 257-68. PMID: 8609160
3. Identification of a major co-receptor for primary isolates of HIV-1.  |  Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
4. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.  |  Bleul, CC., et al. 1996. Nature. 382: 829-33. PMID: 8752280
5. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.  |  Nagasawa, T., et al. 1996. Nature. 382: 635-8. PMID: 8757135
6. Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs.  |  Koivu, T., et al. 1997. DNA Seq. 7: 217-20. PMID: 9254016

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SDF-4 Antibody (E-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SDF-4 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SDF-4 Antibody (E-12) Specifications

Alternate Product Name: SDF-4

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 196-219

Epitope Target: SDF-4

Epitope Species: human

Product Reactivity/Detection: mature SDF-4 and Cab45 precursor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SDF-4 Antibody (E-12): P: Blocking Peptide