SDF-2 Antibody (J-22): sc-100660

SDF-2 Antibody (J-22) is a mouse monoclonal IgG1 kappa light chain antibody that detects SDF-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SDF-2 antibody (J-22) is available as the non-conjugated form. SDF-2, also known as stromal cell-derived factor-2, plays a crucial role in various biological processes, particularly in the regulation of immune responses and cellular signaling pathways. This 211 amino acid protein is characterized by the presence of three MIR domains and is expressed throughout the body, indicating importance in maintaining physiological functions. SDF-2 shares 92% sequence similarity with mouse counterpart, suggesting a conserved function across mammalian species. SDF-2 secretory nature allows involvement in both exocrine and endocrine signaling, facilitating export of enzymes, hormones, and other signaling molecules into bloodstream or ducts. This export is vital for proper functioning of numerous physiological processes, including hormone regulation and immune system modulation, highlighting SDF-2 significance in health and disease.

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SDF-2 Antibody (J-22) References:

1. SDF-2 induction of terminal differentiation in Dictyostelium discoideum is mediated by the membrane-spanning sensor kinase DhkA.  |  Wang, N., et al. 1999. Mol Cell Biol. 19: 4750-6. PMID: 10373524
2. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.  |  Meunier, L., et al. 2002. Mol Biol Cell. 13: 4456-69. PMID: 12475965
3. The Golgi-associated protein GRASP is required for unconventional protein secretion during development.  |  Kinseth, MA., et al. 2007. Cell. 130: 524-34. PMID: 17655921
4. Transcript analyses of stromal cell derived factors (SDFs): SDF-2, SDF-4 and SDF-5 reveal a different pattern of expression and prognostic association in human breast cancer.  |  Kang, H., et al. 2009. Int J Oncol. 35: 205-11. PMID: 19513569
5. Arabidopsis stromal-derived Factor2 (SDF2) is a crucial target of the unfolded protein response in the endoplasmic reticulum.  |  Schott, A., et al. 2010. J Biol Chem. 285: 18113-21. PMID: 20378538
6. Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.  |  Fujimori, T., et al. 2017. Genes Cells. 22: 684-698. PMID: 28597544
7. The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset.  |  Lorenzon-Ojea, AR., et al. 2020. Biochim Biophys Acta Mol Basis Dis. 1866: 165386. PMID: 30776414
8. SDF2-like protein 1 (SDF2L1) regulates the endoplasmic reticulum localization and chaperone activity of ERdj3 protein.  |  Hanafusa, K., et al. 2019. J Biol Chem. 294: 19335-19348. PMID: 31624144
9. Stromal Cell-Derived Factor (SDF) 2 and the Endoplasmic Reticulum Stress Response of Trophoblast Cells in Gestational Diabetes Mellitus and In vitro Hyperglycaemic Condition.  |  Lorenzon, AR., et al. 2021. Curr Vasc Pharmacol. 19: 201-209. PMID: 32504504
10. Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review).  |  Gong, W., et al. 2021. Int J Mol Med. 47: 435-443. PMID: 33416125
11. Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method.  |  Hamada, T., et al. 1996. Gene. 176: 211-4. PMID: 8918255
12. [Regulation of the malic enzyme activity of Acinetobacter by organic acids].  |  Kleber, HP. and Aurich, H. 1976. Z Allg Mikrobiol. 16: 91-5. PMID: 9741

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SDF-2 Antibody (J-22) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SDF-2 Antibody (J-22) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SDF-2 Antibody (J-22) Specifications

Alternate Product Name: SDF-2

Product Clone Name: J-22

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 20-211

Epitope Target: SDF-2

Epitope Species: human

Product Reactivity/Detection: SDF-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SDF-2 Antibody (J-22): N/A