Molecular structure of Scriptaid, CAS Number: 287383-59-9
Scriptaid (CAS 287383-59-9)
See product citations (11)
Alternate Names:
6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Application:
Scriptaid is an HDAC1, HDAC3, and HDAC8 inhibitor
CAS Number:
287383-59-9
Purity:
>95%
Molecular Weight:
326.35
Molecular Formula:
C18H18N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Scriptaid is an HDAC inhibitor (histone deacetylase). HDACs are modifying enzymes that are involved in the regulation of gene transcription, cell proliferation, and chromosome remodeling. Scriptaid has been reported to inhibit all three class I HDACs (HDAC1, HDAC3, HDAC8). Breast cancer cell studies demonstrate that Scriptaid, in combination with 5-Aza-2′-Deoxycytidine (sc-202424), elevates the expression of the estrogen receptor alpha. Scriptaid has been described to reactivate the latent HIV-1 promoter in Jurkat T cell lines, and elicit glioma cell apoptosis by activating JNK and blocking telomerase activity. Nullscript (sc-222084) serves as the negative control for Scriptaid.
Scriptaid (CAS 287383-59-9) References
- A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. | Su, GH., et al. 2000. Cancer Res. 60: 3137-42. PMID: 10866300
- Identification of novel isoform-selective inhibitors within class I histone deacetylases. | Hu, E., et al. 2003. J Pharmacol Exp Ther. 307: 720-8. PMID: 12975486
- A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. | Keen, JC., et al. 2003. Breast Cancer Res Treat. 81: 177-86. PMID: 14620913
- HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. | Sharma, V., et al. 2010. J Cell Mol Med. 14: 2151-61. PMID: 19583803
- Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines. | Ying, H., et al. 2010. Int J Mol Med. 26: 265-72. PMID: 20596607
- Scriptaid improves in vitro development and nuclear reprogramming of somatic cell nuclear transfer bovine embryos. | Wang, LJ., et al. 2011. Cell Reprogram. 13: 431-9. PMID: 21774687
- Scriptaid effects on breast cancer cell lines. | Giacinti, L., et al. 2012. J Cell Physiol. 227: 3426-33. PMID: 22213035
- Scriptaid Upregulates Expression of Development-Related Genes, Inhibits Apoptosis, and Improves the Development of Somatic Cell Nuclear Transfer Mini-Pig Embryos. | Zhang, L., et al. 2017. Cell Reprogram. 19: 19-26. PMID: 28055234
- Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice. | Gaur, V., et al. 2017. Diabetes Obes Metab. 19: 936-943. PMID: 28155245
- Scriptaid improves the reprogramming of donor cells and enhances canine-porcine interspecies embryo development. | No, JG., et al. 2018. Reprod Biol. 18: 18-26. PMID: 29162325
- Scriptaid inhibits cell survival, cell cycle, and promotes apoptosis in multiple myeloma via epigenetic regulation of p21. | Yao, R., et al. 2018. Exp Hematol. 60: 63-72. PMID: 29305109
- Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin. | Huang, S., et al. 2020. J Appl Physiol (1985). 128: 276-285. PMID: 31829803
- Anti-Cancer Effects of Epigenetics Drugs Scriptaid and Zebularine in Human Breast Adenocarcinoma Cells. | Yap, ZH., et al. 2022. Anticancer Agents Med Chem. 22: 1582-1591. PMID: 34102995
Inhibitor of:
2810408P10Rik, 5-Methylcytidine, A530032D15Rik, ACTR6, BAZ1A, CAF-1 p150, DNHD1, DNHD2, EG385328, Elongin C, GAGE7B, GPI-PLD, H2-M10.2, H2AL1, H2al3, HAT1, HBO1, hCG_1795065, HDAC1, HDAC10, HDAC11, HDAC3, HDAC4, HDAC5, HDAC8, Hils1, Histone cluster 1 H2AA, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2AO, Histone cluster 1 H2BG, Histone cluster 1 H2BH, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H2BM, Histone cluster 1 H3G, Histone cluster 1 H3J, Histone cluster 1 H4I, Histone cluster 1 H4L, Histone cluster 2 H2AA1, Histone cluster 2 H2BE, Histone H1, Histone H10, Histone H2A, Histone H2B, Histone H3, ING5, KRTAP4-7, Lce1g, Lipocalin-11, LOC643072, LRWD1, mage-k1, MIER1, MOF, Morc, MORF, MrgB8, NAP5, OCIAD1, OTTMUSG00000010747, OTTMUSG00000018481, pan-Acetyl, PCDHGA8, Peg10, Pi15, RP2, SAP 130, Sin3, SMCHD1, SNF2L, stefin A3L1, Subh2bv, TADA3L, TBC1D24, TGase6, TSHZ3, V1RH18, and ZSCAN4B.Activator of:
4930557A04Rik, ADA3, ATXN7L2, BAHD1, Brpf1, CAF-1 p150, CRSP150_CRSP2, Dnmt3a, Dnmt3b, EG210583, EG210853, EG333452, EG546205, GCN5, GPATCH3, HAT1, HDA5, HDA6, HIC-1, Histone cluster 1 H2A, Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BI, Histone cluster 1 H2BJ, Histone cluster 1 H3C, Histone cluster 1 H3D, Histone cluster 1 H3E, Histone cluster 1 H3J, Histone cluster 1 H4F, Histone cluster 1 H4G, Histone cluster 1 H4L, Histone cluster 2 H3C, Histone cluster 2 H3D, Histone cluster 2 H4, Histone cluster 3 H2ba, Histone H2B.S, HMG-14, hnRNP H′/hnRNP H2, HP1γ, INO80B, JNK, LANPL, LOC100041230, MBD1, MEAF6, Med22, MOF, MRG15, MSL-1, PRAMEF17, SCML1, SMC3, Spt7, TAF II p135, TAF II p28, ZNF469, ZNF579, and ZNF620.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Scriptaid, 1 mg | sc-202807 | 1 mg | $64.00 | |||
Scriptaid, 5 mg | sc-202807A | 5 mg | $183.00 |