Date published: 2025-10-16

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Scopine (CAS 498-45-3)

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Alternate Names:
7-Epoxytropine
Application:
Scopine is a metabolite of scopolamine
CAS Number:
498-45-3
Molecular Weight:
155.19
Molecular Formula:
C8H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Scopine, a tropane alkaloid, serves as a fundamental building block in the synthesis of more complex bioactive compounds, particularly in organic and medicinal chemistry research. The molecule exhibits a distinct bicyclic structure characteristic of tropane alkaloids, which includes a nitrogen bridge that plays a critical role in its chemical behavior and interaction with various biological systems. Scopine is particularly valued for its utility as a precursor in the synthesis of scopine esters and analogs, which are explored for their potential interactions with muscarinic acetylcholine receptors. These interactions is studied to understand the modulation of neurotransmitter systems, especially in neurobiological and pharmacological studies. The ability of scopine and its derivatives to bind to these receptors can inform the design of new compounds that mimic or modulate biological pathways, offering insights into receptor dynamics and aiding in the exploration of nervous system functions.


Scopine (CAS 498-45-3) References

  1. A monoclonal antibody to scopolamine and its use for competitive enzyme-linked immunosorbent assay.  |  Kikuchi, Y., et al. 1991. Phytochemistry. 30: 3273-6. PMID: 1367787
  2. [Analysis of anisodine and its metabolites in rat plasma by liquid chromatography-tandem mass spectrometry].  |  Chen, HX., et al. 2006. Yao Xue Xue Bao. 41: 518-21. PMID: 16927825
  3. Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry.  |  Chen, H., et al. 2007. J Pharm Biomed Anal. 44: 773-8. PMID: 17433600
  4. Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of in vivo and in vitro metabolites of scopolamine in rats.  |  Chen, H., et al. 2008. J Chromatogr Sci. 46: 74-80. PMID: 18218192
  5. Analysis of scopolamine and its eighteen metabolites in rat urine by liquid chromatography-tandem mass spectrometry.  |  Chen, H., et al. 2005. Talanta. 67: 984-91. PMID: 18970269
  6. The distorted tropane of scopoline.  |  Écija, P., et al. 2013. Chemphyschem. 14: 1830-5. PMID: 23640872
  7. Electron-impact ionization detection of scopolamine by gas chromatography-mass spectrometry in rat plasma and brain.  |  Deutsch, J., et al. 1990. J Chromatogr. 528: 325-31. PMID: 2384572
  8. The effect of transdermal scopolamine for the prevention of postoperative nausea and vomiting.  |  Antor, MA., et al. 2014. Front Pharmacol. 5: 55. PMID: 24782768
  9. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil.  |  Wang, X., et al. 2014. Bioconjug Chem. 25: 2046-54. PMID: 25350514
  10. Atropine- and scopolamine-resistant subtypes of muscarinic receptors in the rabbit aorta.  |  Manjeet, S. and Sim, MK. 1989. Eur J Pharmacol. 174: 99-105. PMID: 2612581
  11. Scopine Isolated in the Gas Phase.  |  Écija, P., et al. 2016. Chemphyschem. 17: 3030-3034. PMID: 27338110
  12. Effect of tea making and boiling processes on the degradation of tropane alkaloids in tea and pasta samples contaminated with Solanaceae seeds and coca leaf.  |  Marín-Sáez, J., et al. 2019. Food Chem. 287: 265-272. PMID: 30857698
  13. Simple radioligand binding assay for the determination of urinary scopolamine.  |  Scheurlen, M., et al. 1984. J Pharm Sci. 73: 561-3. PMID: 6726646

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Scopine, 25 mg

sc-338580A
25 mg
$230.00

Scopine, 50 mg

sc-338580
50 mg
$465.00

Scopine, 100 mg

sc-338580B
100 mg
$729.00