SCMH1 Antibody (7-RY14): sc-135621

SCMH1 Antibody (7-RY14) is a mouse monoclonal IgG2a kappa light chain antibody that detects SCMH1 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SCMH1 antibody (7-RY14) is available as non-conjugated. SCMH1, also known as sex comb on midleg homolog 1 or Scml3, plays a crucial role in gene expression regulation through involvement in polycomb group (PcG) proteins, which maintain transcriptionally repressed states of target genes via chromatin modification. SCMH1 is predominantly expressed in testis, where SCMH1 facilitates germ cell maturation and contributes to male reproductive processes. SCMH1 undergoes alternative splicing, resulting in multiple isoforms that may have distinct functions or regulatory roles. SCMH1 is located on human chromosome 1, a significant genomic region spanning 260 million base pairs and containing over 3,000 genes, including many associated with familial adenomatous polyposis and Parkinson′s disease. Chromosome 1 integrity is vital, as aberrations in this region are implicated in several cancers, including head and neck cancer and malignant melanoma, highlighting SCMH1′s importance in both normal physiology and disease states.

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SCMH1 Antibody (7-RY14) References:

1. The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.  |  Berger, J., et al. 1999. Gene. 237: 185-91. PMID: 10524249
2. A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro.  |  Tomotsune, D., et al. 1999. Differentiation. 65: 229-39. PMID: 10653359
3. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.  |  Levine, SS., et al. 2002. Mol Cell Biol. 22: 6070-8. PMID: 12167701
4. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.  |  Takada, Y., et al. 2007. Development. 134: 579-90. PMID: 17215307
5. Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.  |  Wu, HH. and Su, B. 2008. BMC Evol Biol. 8: 192. PMID: 18601738
6. Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.  |  Ohtsubo, M., et al. 2008. Proc Natl Acad Sci U S A. 105: 10396-401. PMID: 18650381
7. The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein.  |  Bornemann, D., et al. 1996. Development. 122: 1621-30. PMID: 8625848