Molecular structure of SCH 442416, CAS Number: 316173-57-6
SCH 442416 (CAS 316173-57-6)
See product citations (3)
Application:
SCH 442416 is an Adenosine A2A-R antagonist
CAS Number:
316173-57-6
Purity:
>99%
Molecular Weight:
389.41
Molecular Formula:
C20H19N7O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SCH 442416 acts as an Adenosine A2A-R antagonist displaying high selectivity and affinity. In vitro experiments resulted in a selectivity of >23000-fold for human Adenosine A2A-R over human Adenosine A1-R while simultaneously displaying minimal affinity for human Adenosine A2B-R and human Adenosine A3-R.
SCH 442416 (CAS 316173-57-6) References
- Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography. | Todde, S., et al. 2000. J Med Chem. 43: 4359-62. PMID: 11087559
- Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists. | Orru, M., et al. 2011. PLoS One. 6: e16088. PMID: 21264319
- Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum. | Orrú, M., et al. 2011. Neuropharmacology. 61: 967-74. PMID: 21752341
- In vitro effect of adenosine A2A receptor antagonist SCH 442416 on the expression of glutamine synthetase and glutamate aspartate transporter in rat retinal Müller cells at elevated hydrostatic pressure. | Yu, J., et al. 2012. Oncol Rep. 27: 748-52. PMID: 22134673
- Effect of A(2A) receptor antagonist (SCH 442416) on the mRNA expression of glutamate aspartate transporter and glutamine synthetase in rat retinal Müller cells under hypoxic conditions in vitro. | Yu, J., et al. 2012. Exp Ther Med. 3: 803-806. PMID: 22969972
- The effect of A 2A receptor antagonist (SCH 442416) on the mRNA expression of Kir 2.1 and Kir 4.1 channels in rat retinal Müller cells under hypoxic conditions in vitro. | Kang, X., et al. 2013. Adv Clin Exp Med. 22: 825-9. PMID: 24431311
- Effects of adenosine A2A receptor antagonists on cocaine-induced locomotion and cocaine seeking. | Haynes, NS., et al. 2019. Psychopharmacology (Berl). 236: 699-708. PMID: 30392131
- Adenosine receptors regulate exosome production. | Ludwig, N., et al. 2020. Purinergic Signal. 16: 231-240. PMID: 32440820
- A2AR Antagonists Upregulate Expression of GS and GLAST in Rat Hypoxia Model. | Yu, J., et al. 2020. Biomed Res Int. 2020: 2054293. PMID: 33195689
- GW-2974 and SCH-442416 modulators of tyrosine kinase and adenosine receptors can also stabilize human telomeric G-quadruplex DNA. | Salem, AA., et al. 2022. PLoS One. 17: e0277963. PMID: 36476719
Inhibitor of:
Adenosine A2A-R, ALG14, Cdc35, Neuropeptide S, and Spitz.Activator of:
NICE4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCH 442416, 1 mg | sc-204271 | 1 mg | $95.00 | |||
| US: Only available in the US | ||||||
SCH 442416, 10 mg | sc-204271A | 10 mg | $245.00 | |||
| US: Only available in the US | ||||||