Molecular structure of SCH 28080, CAS Number: 76081-98-6
SCH 28080 (CAS 76081-98-6)
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Alternate Names:
2-methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile
Application:
SCH 28080 is a potent inhibitor of H+,K+-ATPase
CAS Number:
76081-98-6
Purity:
≥98%
Molecular Weight:
277.32
Molecular Formula:
C17H15N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM). SCH 28080 binds to the K+ recognition site and is competitive with respect to K+. Also inhibits gastric acid secretion in vitro. It operates through the inhibition of cyclooxygenase-2 (COX-2), an enzyme responsible for producing prostaglandins.
SCH 28080 (CAS 76081-98-6) References
- Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820. | Swarts, HG., et al. 1999. Mol Pharmacol. 55: 541-7. PMID: 10051539
- A chimeric gastric H+,K+-ATPase inhibitable with both ouabain and SCH 28080. | Asano, S., et al. 1999. J Biol Chem. 274: 6848-54. PMID: 10066737
- Inhibition of vascular smooth muscle tone by the H+, K+-ATPase inhibitor SCH 28080. | Rhoden, KJ. 2000. J Pharm Pharmacol. 52: 857-62. PMID: 10933137
- Sch-28080 depletes intracellular ATP selectively in mIMCD-3 cells. | Codina, J., et al. 2000. Am J Physiol Cell Physiol. 279: C1319-26. PMID: 11029278
- A hybrid between Na+,K+-ATPase and H+,K+-ATPase is sensitive to palytoxin, ouabain, and SCH 28080. | Farley, RA., et al. 2001. J Biol Chem. 276: 2608-15. PMID: 11054424
- The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump. | Asano, S., et al. 2004. J Biol Chem. 279: 13968-75. PMID: 14699149
- SCH 28080 is a lumenally acting, K+-site inhibitor of the gastric (H+ + K+)-ATPase. | Keeling, DJ., et al. 1988. Biochem Pharmacol. 37: 2231-6. PMID: 2837231
- The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells. | Jakab, M., et al. 2017. Cell Physiol Biochem. 43: 1037-1051. PMID: 28968600
- Inhibition of H+K+ATPase by SCH 28080 and SCH 32651. | Scott, CK. and Sundell, E. 1985. Eur J Pharmacol. 112: 268-70. PMID: 2993001
- Gastric antisecretory and cytoprotective activities of SCH 28080. | Long, JF., et al. 1983. J Pharmacol Exp Ther. 226: 114-20. PMID: 6864535
- A study of the inhibitory effects of SCH 28080 on gastric secretion in man. | Ene, MD., et al. 1982. Br J Pharmacol. 76: 389-91. PMID: 7104515
- Sch-28080 inhibits bafilomycin-sensitive H+ secretion in turtle bladder independently of luminal [K+]. | Kohn, OF., et al. 1993. Am J Physiol. 265: F174-9. PMID: 8368331
- Mutational analysis of putative SCH 28080 binding sites of the gastric H+,K+-ATPase. | Asano, S., et al. 1997. J Biol Chem. 272: 17668-74. PMID: 9211917
- Dietary K+ restriction upregulates total and Sch-28080-sensitive bicarbonate absorption in rat tIMCD. | Wall, SM., et al. 1998. Am J Physiol. 275: F543-9. PMID: 9755126
Inhibitor of:
ATPase, and H+/K+ ATPase β.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCH 28080, 10 mg | sc-204269 | 10 mg | $281.00 | |||
SCH 28080, 50 mg | sc-204269A | 50 mg | $988.00 |