Date published: 2025-12-19

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SC10 (CAS 102649-79-6)

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Alternate Names:
5-Chloro-N-heptyl-1-naphthalenesulfonamide
Application:
SC10 is a protein kinase C (PKC) activator
CAS Number:
102649-79-6
Purity:
98%
Molecular Weight:
339.9
Molecular Formula:
C17H22CINO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SC10 is a highly effective compound that activates PKC, a protein kinase involved in numerous cellular processes. It has the ability to penetrate cells and specifically activates PKC in a calcium-dependent manner. One of its notable effects is the restoration of the disrupted interaction between hTERT and hsp90, which are essential components of the telomerase holoenzyme, counteracting the inhibitory effects of novobiocin. Furthermore, SC10 exerts its PKC-activating action by directly stimulating the phosphorylation of myosin light chain (MLC) through PKC, without involving the activation of MLC kinase. This distinct mechanism of action sets SC10 apart from other PKC activators, making it a valuable compound for research.


SC10 (CAS 102649-79-6) References

  1. Contribution of protein kinase C to central sensitization and persistent pain following tissue injury.  |  Coderre, TJ. 1992. Neurosci Lett. 140: 181-4. PMID: 1501774
  2. Transcriptomic analysis of a near-isogenic line of melon with high fruit flesh firmness during ripening.  |  Zarid, M., et al. 2021. J Sci Food Agric. 101: 754-777. PMID: 32713003
  3. Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity.  |  Danielewski, M., et al. 2022. Oxid Med Cell Longev. 2022: 1504929. PMID: 35340213
  4. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C.  |  Ito, M., et al. 1986. Biochemistry. 25: 4179-84. PMID: 3756133
  5. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase.  |  Nishino, H., et al. 1986. Biochim Biophys Acta. 889: 236-9. PMID: 3778949

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SC10, 1 mg

sc-202335
1 mg
$31.00

SC10, 5 mg

sc-202335A
5 mg
$102.00