Molecular structure of SC1 (Pluripotin), CAS Number: 839707-37-8
SC1 (Pluripotin) (CAS 839707-37-8)
Alternate Names:
N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Application:
SC1 (Pluripotin) is a sustainer of mES self-renewal and ERK 1 inhibitor
CAS Number:
839707-37-8
Molecular Weight:
550.54
Molecular Formula:
C27H25F3N8O2
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SC1 (Pluripotin) is a small molecule shown to sustain self-renewal of mouse embryonic stem (mES) cells. In order to maintain embryonic stem cells in an undifferentiated state, it is typically necessary to use a combination of feeder cells, leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) SC1 (Pluripotin) allows for stem cell propagation in the absence of these factors. The activity of SC1 (Pluripotin) is mediated by Ras signaling which promotes self-renewal, and inhibition of ERK blocks differentiation.
SC1 (Pluripotin) (CAS 839707-37-8) References
- Self-renewal of embryonic stem cells by a small molecule. | Chen, S., et al. 2006. Proc Natl Acad Sci U S A. 103: 17266-71. PMID: 17088537
- Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. | Yang, W., et al. 2009. Stem Cells. 27: 383-9. PMID: 19056907
- The use of SC1 (Pluripotin) to support mESC self-renewal in the absence of LIF. | Xiong, W., et al. 2009. J Vis Exp.. PMID: 19924098
- Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells. | Pieters, T., et al. 2012. Stem Cell Rev Rep. 8: 768-78. PMID: 22011883
- Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. | Duan, H., et al. 2012. Exp Eye Res. 100: 52-8. PMID: 22564971
- Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells. | Wu, Y., et al. 2013. Mol Biol Rep. 40: 2897-906. PMID: 23254757
- A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. | Mertins, SD., et al. 2013. PLoS One. 8: e57099. PMID: 23437320
- Small molecules affect human dental pulp stem cell properties via multiple signaling pathways. | Al-Habib, M., et al. 2013. Stem Cells Dev. 22: 2402-13. PMID: 23573877
- E-cadherin is critical for SC1-induced colony growth of F9 embryonic carcinoma cells. | Du, J., et al. 2014. Cell Physiol Biochem. 33: 501-12. PMID: 24556957
- Improved derivation efficiency and pluripotency of stem cells from the refractory inbred C57BL/6 mouse strain by small molecules. | Lin, CJ., et al. 2014. PLoS One. 9: e106916. PMID: 25211343
- SC1 inhibits the differentiation of F9 embryonic carcinoma cells induced by retinoic acid. | Liu, Y., et al. 2018. Acta Biochim Biophys Sin (Shanghai). 50: 793-799. PMID: 29945210
- SC1 sustains the self-renewal capacity and pluripotency of chicken blastodermal cells by inhibiting the phosphorylation of ERK1 and promoting the phosphorylation of Akt. | Li, R., et al. 2018. Reprod Domest Anim. 53: 1052-1059. PMID: 30028046
- The role of 5-hydroxymethylcytosine in mitochondria after ischemic stroke. | Ji, F., et al. 2018. J Neurosci Res. 96: 1717-1726. PMID: 30043506
- Transcriptome Profiling of Acquired Gefitinib Resistant Lung Cancer Cells Reveals Dramatically Changed Transcription Programs and New Treatment Targets. | Wei, N., et al. 2020. Front Oncol. 10: 1424. PMID: 32923394
- Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML. | Azhar, M., et al. 2023. Blood Adv. 7: 1460-1476. PMID: 36044389
Inhibitor of:
DPPA2, ERK 1, ESC, FKBP12, Myosin, Oct-3A, PABPC4, Pcf11, PRPF18, SAP 14_SF3B14, Ser/Thr Protein Kinase, Sm G, and TLR7.Activator of:
KLC1, and Snk.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SC1 (Pluripotin), 1 mg | sc-255607 | 1 mg | $164.00 | |||
SC1 (Pluripotin), 5 mg | sc-255607A | 5 mg | $195.00 | |||
SC1 (Pluripotin), 10 mg | sc-255607B | 10 mg | $464.00 | |||
SC1 (Pluripotin), 25 mg | sc-255607C | 25 mg | $764.00 |