Molecular structure of SC 58125, CAS Number: 162054-19-5
SC 58125 (CAS 162054-19-5)
Alternate Names:
5-(4-fluorophenyl)-1-(4-methylsulfonylphenyl)-3-(trifluoromethyl)pyrazole
Application:
SC 58125 is a selective Cox-2 inhibitor
CAS Number:
162054-19-5
Molecular Weight:
384.35
Molecular Formula:
C17H12F4N2O2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SC 58125 is a selective, time-dependent, and irreversible cyclooxygenase-2 (Cox-2) inhibitor that displays anti-inflammatory properties. In addition to inhibiting Cox-2 (IC50 of 0.04 μM), SC 58125 is found to reversibly inhibit Cox-1 (IC50 of >100 μM), which is expressed in most tissues and organs. Experiments suggest that SC 58125 is also capable of suppressing cell proliferation by causing a progression delay at the G2/M transition.
SC 58125 (CAS 162054-19-5) References
- Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC 58125, aggravates postischaemic cardiac dysfunction, independent of COX function. | Heindl, B. and Becker, BF. 2001. Naunyn Schmiedebergs Arch Pharmacol. 363: 233-40. PMID: 11218076
- A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. | Williams, CS., et al. 2001. Neoplasia. 3: 428-36. PMID: 11687954
- The Role of Cyclooxygenase-2 in Inflammation. | Masferrer, JL., et al. 1995. Am J Ther. 2: 607-610. PMID: 11854834
- Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. | Bottone, FG., et al. 2004. Carcinogenesis. 25: 349-57. PMID: 14633654
- Participation of cyclooxygenase-1 in prostaglandin E2 release from synovitis tissue in primary osteoarthritis in vitro. | Knorth, H., et al. 2004. Osteoarthritis Cartilage. 12: 658-66. PMID: 15262246
- Inhibitory effects of Celecoxib and Sc-58125 on proliferation of human carcinoma of larynx Hep-2 in vitro. | Ding, J., et al. 2005. J Huazhong Univ Sci Technolog Med Sci. 25: 202-5. PMID: 16116973
- Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric oxide synthase and consequent S-nitrosylation of cyclooxygenase-2. | Atar, S., et al. 2006. Am J Physiol Heart Circ Physiol. 290: H1960-8. PMID: 16339820
- Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. | Ryan, EP., et al. 2008. Cancer Immunol Immunother. 57: 347-58. PMID: 17668203
- Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. | Seibert, K., et al. 1994. Proc Natl Acad Sci U S A. 91: 12013-7. PMID: 7991575
- A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. | Gierse, JK., et al. 1996. J Biol Chem. 271: 15810-4. PMID: 8663121
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SC 58125, 10 mg | sc-204267 | 10 mg | $113.00 | |||
SC 58125, 50 mg | sc-204267A | 50 mg | $550.00 |