SC 560 (CAS 188817-13-2)
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SC 560 is reported to be a Cox-1 and Cox-2 inhibitor, and is highly selective for Cox-1 (IC50 of 0.009 μM) over Cox-2 (IC50 of 6.3 μM). SC 560 also inhibits UTP-stimulated and basal cAMP levels. Cox-1 is shown to catalyze the conversion of arachidonic acid (sc-200770) into PGH2 (Prostaglandin H2, sc-201266), which is the precursor of thromboxanes and other prostaglandins, therefore SC 560 also suppresses thromboxane B2 (TXB2, sc-201452) and prostaglandin E2 (PGE2, sc-201225) production. SC 560 also displays the ability to induce cell growth inhibition by causing cell cycle arrest at the G1 phase. Mechanistic studies show that SC 560 causes apoptosis of cells by eliciting reactive oxygen species and simultaneously decreasing the levels of anti-apoptotic proteins XIAP and survivin. Additional experiments suggest that SC 560 also activates caspase-3 and -7 which result in apoptosis of cells.
SC 560 (CAS 188817-13-2) References
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- Manipulation of phototransductive membrane turnover by crab photoreceptors in vitro: effects of two protein kinase activators, SC-9 and phorbol ester in the presence of a protein phosphatase inhibitor, okadaic acid. | Blest, AD., et al. 1992. J Comp Physiol A. 170: 189-99. PMID: 1316437
- 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole acts in a reactive oxygen species-dependent manner to suppress human lung cancer growth. | Lee, E., et al. 2006. J Cancer Res Clin Oncol. 132: 223-33. PMID: 16362334
- The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. | Lampiasi, N., et al. 2006. Int J Mol Med. 17: 245-52. PMID: 16391822
- The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2. | Inoue, A., et al. 2006. Neurosci Lett. 401: 242-7. PMID: 16580130
- Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. | Brenneis, C., et al. 2006. FASEB J. 20: 1352-60. PMID: 16816110
- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells. | Lee, E., et al. 2006. Exp Mol Med. 38: 325-31. PMID: 16819292
- Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. | Cusimano, A., et al. 2007. Cancer Biol Ther. 6: 1461-8. PMID: 18424914
- Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. | Choi, SH., et al. 2013. J Neurochem. 124: 59-68. PMID: 23083210
- Ghrelin Protection against Cytotoxic Effect of Ethanol on Rat Salivary Mucin Synthesis involves Cytosolic Phospholipase A2 Activation through S-Nitrosylation. | Slomiany, BL. and Slomiany, A. 2010. Int J Biomed Sci. 6: 37-44. PMID: 23675174
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SC 560, 5 mg | sc-202805 | 5 mg | $77.00 |