Molecular structure of SC 19220, CAS Number: 19395-87-0
SC 19220 (CAS 19395-87-0)
See product citations (2)
Alternate Names:
8-chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxy-(2-acetyl)hydrazide
Application:
SC 19220 is a selective EP1 receptor antagonist
CAS Number:
19395-87-0
Molecular Weight:
331.76
Molecular Formula:
C16H14ClN3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SC 19220 is a compound that is mainly used in biochemical research due to its properties as an antagonist to specific receptors. It is particularly valuable in studies aimed at understanding the role of these receptors in physiological and pathological processes. Researchers employ SC 19220 to investigate the modulation of signaling pathways, which can provide insights into the mechanisms of action for various cellular responses. This compound is also instrumental in receptor-ligand interaction studies, where it can help delineate the binding characteristics and specificity of receptors. In addition, SC 19220 is used to characterize the downstream effects of receptor inhibition in cell-based assays, contributing to a broader understanding of intracellular communication and regulation.
SC 19220 (CAS 19395-87-0) References
- SC-19220, a prostaglandin E2 antagonist, inhibits osteoclast formation by 1,25-dihydroxyvitamin D3 in cell cultures. | Inoue, H., et al. 1999. J Endocrinol. 161: 231-6. PMID: 10320820
- Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. | Santangelo, S., et al. 2000. J Trauma. 48: 826-30; discussion 830-1. PMID: 10823525
- Effects of prostaglandin antagonist SC-19220 on body temperature and on hyperthermic responses to prostaglandin E-1 and leukocytic pyrogen in the cat. | Clark, WG. and Cumby, HR. 1975. Prostaglandins. 9: 361-8. PMID: 1138292
- Contractile effects of prostaglandin E2 in rat rectum: sensitivity to the prostaglandin antagonists diphloretin phosphate and SC 19220. | Vassilev, P. and Radomirov, R. 1992. Prostaglandins. 44: 471-83. PMID: 1361677
- SC-19220, antagonist of prostaglandin E2 receptor EP1, inhibits osteoclastogenesis by RANKL. | Tsujisawa, T., et al. 2005. J Bone Miner Res. 20: 15-22. PMID: 15619665
- Presynaptic prostaglandin E2 EP1-receptor facilitation of cerebral nitrergic neurogenic vasodilation. | Jadhav, V., et al. 2009. Stroke. 40: 261-9. PMID: 18948615
- Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphate. | Mikalsen, SO., et al. 1990. Cell Biol Toxicol. 6: 1-13. PMID: 2334865
- The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. | Maggi, CA., et al. 1988. Eur J Pharmacol. 152: 273-9. PMID: 2906002
- Effect of selective inhibition or activation of PGE2 EP1 receptor on glomerulosclerosis. | Chen, X., et al. 2020. Mol Med Rep. 22: 2887-2895. PMID: 32700746
- EP1 receptor antagonism mitigates early and late stage renal fibrosis. | Kresse, JC., et al. 2022. Acta Physiol (Oxf). 234: e13780. PMID: 34989478
- Antagonism of tone and prostaglandin-mediated responses in a tracheal preparation by indomethacin and SC-19220. | Farmer, JB., et al. 1974. Br J Pharmacol. 52: 559-65. PMID: 4455330
- Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E1, E2 and F2 alpha. | Rakovska, A. and Milenov, K. 1984. Arch Int Pharmacodyn Ther. 268: 59-69. PMID: 6145394
- Receptor subtypes involved in dual effects induced by prostaglandin E2 in circular smooth muscle from dog colon. | Botella, A., et al. 1995. J Pharmacol Exp Ther. 273: 1008-14. PMID: 7791070
- Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. | Funk, CD., et al. 1993. J Biol Chem. 268: 26767-72. PMID: 8253813
Inhibitor of:
EP1, EP3, and Gα s.Activator of:
EP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SC 19220, 1 mg | sc-203450B | 1 mg | $22.00 | |||
SC 19220, 5 mg | sc-203450C | 5 mg | $104.00 | |||
SC 19220, 10 mg | sc-203450 | 10 mg | $184.00 | |||
SC 19220, 50 mg | sc-203450A | 50 mg | $797.00 |