Molecular structure of SB203186, CAS Number: 135938-17-9
Molecular structure of SB203186, CAS Number: 135938-17-9
Molecular structure of SB203186, CAS Number: 135938-17-9
SB203186 (CAS 135938-17-9)
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Alternate Names:
1-Piperidinylethyl-1H-indole-3-carboxylate
Application:
SB203186 is a potent 5HT4 serotonin receptor antagonist
CAS Number:
135938-17-9
Molecular Weight:
308.81
Molecular Formula:
C16H20N2O2 HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SB203186 is a potent 5-HT4 serotonin receptor antagonist.
SB203186 (CAS 135938-17-9) References
Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium: A.D. Medhurst & A.J. Kaumann; Br. J. Pharmacol. 110, 1023 (1993) Do human atrial 5-HT4 receptors mediate arrhythmias?: A.J. Kaumann; TIPS 15, 451 (1994), 5-HT4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex: P.G. McLean & I.M. Coupar; Naunyn-Schmiedeberg's Arch. Pharmacol. 352, 132 (1995) Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186: S.G. Parker, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 353, 28 (1995)
Inhibitor of:
SR-4.
Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at 4° C
Melting Point :
184.5-185.5° C
Boiling Point :
457.8° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 7.94 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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