SB-415286 (CAS 264218-23-7)

SB-415286 is a potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3), a multifunctional serine/threonine kinase involved in various signaling pathways regulating cellular processes such as glycogen metabolism, cell cycle regulation, and gene transcription. The mechanism of action of SB-415286 involves its binding to the ATP-binding pocket of GSK-3, thereby preventing its phosphorylation and subsequent activation. By inhibiting GSK-3, SB-415286 modulates downstream signaling cascades, including the Wnt/β-catenin pathway, which is crucial for embryonic development, cell proliferation, and stem cell maintenance. In scientific research, SB-415286 has been extensively utilized as a pharmacological tool to investigate the role of GSK-3 in cellular physiology and pathology. Studies employing SB-415286 have contributed to the understanding of GSK-3-mediated signaling pathways and their implications in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Additionally, SB-415286 has been instrumental in elucidating the molecular mechanisms underlying the regulation of neuronal function, synaptic plasticity, and memory formation in the central nervous system. Furthermore, SB-415286 has been employed in stem cell research to enhance the efficiency of cellular reprogramming and differentiation, offering insights into the potential of manipulating GSK-3 activity for regenerative medicine applications. Overall, SB-415286 serves as a valuable tool for dissecting the complex roles of GSK-3 in cellular biology and disease pathogenesis, facilitating advancements in basic and translational research.