SB-415286 is an ATP-competitive inhibitor of GSK3α (Glycogen Synthase Kinase 3α) with a Ki value of 31 nM. SB-415286 displays similar potency for GSK-3β. Alternate studies suggest that SB-415286 stabilizes β-catenin, which in turn leads to inhibition of coxsackievirus-induced cell death.
1: A. Carabaza et al. Chirality 1997 9 281
Soluble in DMSO (72 mg/ml at 25° C), ethanol (72 mg/ml at 25° C), and water (< 1 mg/ml at 25° C).
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Rated 5 out of
Jiang et alJiang et al. (PubMed ID 24969790) found that SB-415286 showed a protective effect against radiation-induced necrosis via GSK-3 inhibition. -SCBT Publication Review
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