Molecular structure of SB 399885 hydrochloride, CAS Number: 402713-80-8
SB 399885 hydrochloride (CAS 402713-80-8)
See product citations (1)
Alternate Names:
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamidehydrochloride
Application:
SB 399885 hydrochloride is a SR-6 antagonist
CAS Number:
402713-80-8
Molecular Weight:
482.81
Molecular Formula:
C18H21Cl2N3O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).
SB 399885 hydrochloride (CAS 402713-80-8) References
Hirst et al (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109. Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models fo anxiety and depression. Neuropharmacology 52 1274. Foley et al (2008) The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166.Inhibitor of:
SR-6.Activator of:
D4DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 399885 hydrochloride, 10 mg | sc-204264 | 10 mg | $183.00 | |||
SB 399885 hydrochloride, 50 mg | sc-204264A | 50 mg | $754.00 |