Molecular structure of SB 328437, CAS Number: 247580-43-4
SB 328437 (CAS 247580-43-4)
Alternate Names:
(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
Application:
SB 328437 is a potent, selective CKR-3 (CCR3) antagonist
CAS Number:
247580-43-4
Molecular Weight:
378.38
Molecular Formula:
C21H18N2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis.
SB 328437 (CAS 247580-43-4) References
- Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. | White, JR., et al. 2000. J Biol Chem. 275: 36626-31. PMID: 10969084
- Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. | Abonyo, BO., et al. 2005. Am J Physiol Lung Cell Mol Physiol. 289: L478-88. PMID: 15863444
- Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. | Mori, A., et al. 2007. Int Immunol. 19: 913-21. PMID: 17804691
- RANTES-mediated control of excitatory amino acid release in mouse spinal cord. | Di Prisco, S., et al. 2012. J Neurochem. 121: 428-37. PMID: 22385043
- Inhibitory effect of CCR3 signal on alkali-induced corneal neovascularization. | Zhou, WJ., et al. 2012. Int J Ophthalmol. 5: 251-7. PMID: 22773968
- CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2. | Provost, V., et al. 2013. J Leukoc Biol. 94: 213-22. PMID: 23532518
- CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure. | Kuse, Y., et al. 2017. Front Pharmacol. 8: 207. PMID: 28458639
- Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs. | Filippone, RT., et al. 2018. Neurogastroenterol Motil. 30: e13391. PMID: 29968270
- CCR3 antagonist impairs estradiol-induced eosinophil migration to the uterus in ovariectomized mice. | Araújo, JMD., et al. 2020. Braz J Med Biol Res. 53: e8659. PMID: 31859912
- Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights. | Gutiérrez, Á., et al. 2024. Oncol Lett. 28: 296. PMID: 38737977
Inhibitor of:
CKR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 328437, 5 mg | sc-222292 | 5 mg | $104.00 |