Molecular structure of SB 290157 trifluoroacetate salt, CAS Number: 1140525-25-2
SB 290157 trifluoroacetate salt (CAS 1140525-25-2)
See product citations (10)
Alternate Names:
N2-[(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate
Application:
SB 290157 trifluoroacetate salt is a selective, high affinity, competitive antagonist of anaphylatoxin C3a receptor
CAS Number:
1140525-25-2
Purity:
≥95%
Molecular Weight:
526.50
Molecular Formula:
C22H28N4O4•CF3CO2H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SB 290157 trifluoroacetate salt is a non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3aR (C3a receptor, IC50 = 200 nM). The chemical does not antagonize C5aR or other chemotactic G-protein-coupled receptors. The compound may act to block C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). SB 290157 has also been shown to block C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). In addition, the compound has exhibited antiinflammatory properties.
SB 290157 trifluoroacetate salt (CAS 1140525-25-2) References
- Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. | Ames, RS., et al. 2001. J Immunol. 166: 6341-8. PMID: 11342658
- Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. | Ratajczak, J., et al. 2004. Blood. 103: 2071-8. PMID: 14604969
- Complement factors C3a and C5a have distinct hemodynamic effects in the rat. | Proctor, LM., et al. 2009. Int Immunopharmacol. 9: 800-6. PMID: 19285573
- Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis. | Hutamekalin, P., et al. 2010. J Pharmacol Sci. 112: 56-63. PMID: 20051658
- Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats. | Han, Y., et al. 2012. Am J Hypertens. 25: 284-9. PMID: 22089112
- Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats. | Ikeda, K., et al. 2014. Clin Exp Hypertens. 36: 58-63. PMID: 23713944
- Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice. | Wang, F., et al. 2014. Toxicol Lett. 229: 229-39. PMID: 24974766
- Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. | Halai, R., et al. 2014. Eur J Pharmacol. 745: 176-81. PMID: 25446428
- Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice. | Őrfi, E., et al. 2019. Int J Nanomedicine. 14: 1563-1573. PMID: 30880965
- Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury. | Surugiu, R., et al. 2019. Neural Plast. 2019: 1071036. PMID: 31814819
- C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke. | Ahmad, S., et al. 2020. Br J Pharmacol. 177: 2466-2477. PMID: 31975437
- The 'C3aR Antagonist' SB290157 is a Partial C5aR2 Agonist. | Li, XX., et al. 2020. Front Pharmacol. 11: 591398. PMID: 33551801
- C3/C3aR inhibition alleviates GMH-IVH-induced hydrocephalus by preventing microglia-astrocyte interactions in neonatal rats. | Tang, J., et al. 2022. Neuropharmacology. 205: 108927. PMID: 34921829
- The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter. | Li, B., et al. 2023. Sci Total Environ. 867: 161416. PMID: 36621481
- Macrophages promote heat stress nephropathy in mice via the C3a-C3aR-TNF pathway. | Yang, Y., et al. 2023. Immunobiology. 228: 152337. PMID: 36689826
Inhibitor of:
C3aR, and CD88.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 290157 trifluoroacetate salt, 10 mg | sc-222291 | 10 mg | $166.00 | |||
SB 290157 trifluoroacetate salt, 50 mg | sc-222291A | 50 mg | $624.00 | |||
SB 290157 trifluoroacetate salt, 100 mg | sc-222291B | 100 mg | $1040.00 |