Molecular structure of SB 242084 hydrochloride, CAS Number: 1049747-87-6
SB 242084 hydrochloride (CAS 1049747-87-6)
Application:
SB 242084 hydrochloride is an antagonist of the SR-2C
CAS Number:
1049747-87-6
Purity:
≥98%
Molecular Weight:
467.8
Molecular Formula:
C21H19ClN4O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SB 242084 hydrochloride is a potent and selective antagonist of the SR-2C (5-HT2C receptor) (pKi = 9.0), with at least 100-fold more selectivity over other serotonin, dopamine or adrenergic receptors. In vivo, it is a brain penetrant and has significant anxiolytic activity, without sedative, proconvulsant, or hyperphagic properties. It increases the basal activity of dopaminergic neurons and affects the behavioral responses mediated by 5-HT2C such as mesolimbic neuron activity and food intake. SB 242084 hydrochloride has been used extensively in animal research to evaluate SR-2C agonists and neurotransmitter receptor interactions in mice.
SB 242084 hydrochloride (CAS 1049747-87-6) References
- Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine. | Goudie, AJ., et al. 2004. Psychopharmacology (Berl). 171: 212-22. PMID: 14691616
- Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse. | Dalton, GL., et al. 2006. Psychopharmacology (Berl). 185: 45-57. PMID: 16470405
- The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists. | Fletcher, PJ., et al. 2006. Psychopharmacology (Berl). 187: 515-25. PMID: 16832658
- Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. | Fletcher, PJ., et al. 2009. Neuropharmacology. 57: 259-67. PMID: 19501602
- Directly Observable Behavioral Effects of Lorcaserin in Rats. | Serafine, KM., et al. 2015. J Pharmacol Exp Ther. 355: 381-5. PMID: 26384326
- Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice. | Yamamoto, H., et al. 2017. Neuropharmacology. 112: 188-197. PMID: 27480795
- Lorcaserin Administration has Pro-Ejaculatory Effects in Rats via 5-HT2C Receptors Activation: A Putative Pharmacologic Strategy to Delayed Ejaculation? | de Almeida Kiguti, LR., et al. 2020. J Sex Med. 17: 1060-1071. PMID: 32234370
- SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. | Kennett, GA., et al. 1997. Neuropharmacology. 36: 609-20. PMID: 9225286
- 6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist. | Bromidge, SM., et al. 1997. J Med Chem. 40: 3494-6. PMID: 9357513
Inhibitor of:
pro-MCH, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 242084 hydrochloride, 1 mg | sc-351848 | 1 mg | $100.00 | |||
SB 242084 hydrochloride, 5 mg | sc-351848A | 5 mg | $225.00 |