Molecular structure of SB 239063, CAS Number: 193551-21-2
SB 239063 (CAS 193551-21-2)
See product citations (7)
Alternate Names:
trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole
Application:
SB 239063 is an inhibitor of p38 MAP kinase
CAS Number:
193551-21-2
Purity:
≥97%
Molecular Weight:
368.40
Molecular Formula:
C20H21FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SB 239063 is a potent and selective p38 MAP kinase inhibitor. This chemical displays greater than 220-fold selectivity over ERK, JNK1 and other kinases, is approximately 3-fold more selective than SB 203580, and is selective for p38 alpha and p38 beta with no activity against gamma and delta isoforms. SB 239063 may act to decrease the number of activated microglia and facilitates neurogenesis. It also reduces inflammatory cytokine production and is neuroprotective.
SB 239063 (CAS 193551-21-2) References
- SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence. | Underwood, DC., et al. 2000. J Pharmacol Exp Ther. 293: 281-8. PMID: 10734180
- SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. | Underwood, DC., et al. 2000. Am J Physiol Lung Cell Mol Physiol. 279: L895-902. PMID: 11053025
- Therapeutic potential of anti-inflammatory drugs in focal stroke. | Barone, FC. and Parsons, AA. 2000. Expert Opin Investig Drugs. 9: 2281-306. PMID: 11060807
- SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. | Barone, FC., et al. 2001. J Pharmacol Exp Ther. 296: 312-21. PMID: 11160612
- SB 239063, a novel p38 inhibitor, attenuates early neuronal injury following ischemia. | Legos, JJ., et al. 2001. Brain Res. 892: 70-7. PMID: 11172750
- Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. | Barone, FC., et al. 2001. Med Res Rev. 21: 129-45. PMID: 11223862
- SB-239063, a potent and selective inhibitor of p38 map kinase: preclinical pharmacokinetics and species-specific reversible isomerization. | Ward, KW., et al. 2001. Pharm Res. 18: 1336-44. PMID: 11683250
- p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation. | Gao, F., et al. 2002. Cardiovasc Res. 53: 414-22. PMID: 11827692
- Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury. | Ju, H., et al. 2002. J Pharmacol Exp Ther. 301: 15-20. PMID: 11907152
- The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury. | Legos, JJ., et al. 2002. Eur J Pharmacol. 447: 37-42. PMID: 12106800
- p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging. | Lenhard, SC., et al. 2003. J Pharmacol Exp Ther. 307: 939-46. PMID: 14561850
- Role of p38 MAP kinase in postcapillary venule leukocyte adhesion induced by ischemia/reperfusion injury. | Johns, DG., et al. 2005. Pharmacol Res. 51: 463-71. PMID: 15749461
- Role of p38 mitogen-activated protein kinase in cardiac remodelling. | Frantz, S., et al. 2007. Br J Pharmacol. 150: 130-5. PMID: 17179956
- Effect of the p38 MAPK inhibitor SB-239063 on Lipopolysaccharide-induced psychomotor retardation and peripheral biomarker alterations in rats. | Bison, S., et al. 2011. Eur J Pharmacol. 661: 49-56. PMID: 21545800
- Effects of cytokine-suppressive anti-inflammatory drugs on inflammatory activation in ex vivo human and ovine fetal membranes. | Stinson, LF., et al. 2014. Reproduction. 147: 313-20. PMID: 24493151
Inhibitor of:
Mkk2, MPK-1, Olfr695, Olfr922, p38 alpha, p38γ MAPK12, and Ser/Thr Protein Kinase.Activator of:
Rif1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 239063, 500 µg | sc-220094B | 500 µg | $117.00 | |||
SB 239063, 5 mg | sc-220094 | 5 mg | $159.00 | |||
SB 239063, 25 mg | sc-220094A | 25 mg | $632.00 |