Molecular structure of SB-224289 hydrochloride, CAS Number: 180084-26-8
SB-224289 hydrochloride (CAS 180084-26-8)
Application:
SB-224289 hydrochloride is a selective SR-1B antagonist
CAS Number:
180084-26-8
Molecular Weight:
557.08
Molecular Formula:
C32H32N4O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective 5-HT1B serotonin receptor antagonist
SB-224289 hydrochloride (CAS 180084-26-8) References
Gaster, L.M., et al., The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. J. Med. Chem. 41, 1218, (1998) De Vries, P., et al., The canine external carotid vasoconstrictor 5-HT receptor: blockade by 5-HT1B (SB224289) but not by 5-HT1D (BRL15572) receptor antagonists. Eur. J. Pharmacol. 362, 69-72, (1998) Selkirk, J.V., SB-224289-a novel selective (human) 5HT1B receptor antagonist with negative intrinsic activity. Br. J. Pharmacol. 125, 202, (1998)Inhibitor of:
SR-1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB-224289 hydrochloride, 5 mg | sc-253541 | 5 mg | $194.00 |