SB-215505 (CAS 162100-15-4)
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SB-215505 is a chemical compound extensively studied for its role as a selective antagonist of the 5-HT2B receptor, a subtype of the serotonin receptor. In research applications, SB-215505 is applied to dissect the physiological and biochemical pathways modulated by 5-HT2B receptors. It is particularly useful in neuroscience research aiming to understand the implications of 5-HT2B receptor activity on behavior and neuromodulation. Additionally, SB-215505 is used in cardiovascular studies, as the 5-HT2B receptor has been implicated in cardiac function. Researchers also utilize this compound to explore the molecular signaling events that follow receptor antagonism and to clarify the receptor′s involvement in cell proliferation and the release of certain hormones. Moreover, SB-215505 aids in the differentiation of the roles played by various subtypes of serotonin receptors by providing specific blockade of the 5-HT2B receptor.
SB-215505 (CAS 162100-15-4) References
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- Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. | Vickers, SP., et al. 2001. Neuropharmacology. 41: 200-9. PMID: 11489456
- m-CPP-induced self-grooming is mediated by 5-HT2C receptors. | Graf, M., et al. 2003. Behav Brain Res. 142: 175-9. PMID: 12798279
- Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. | Kantor, S., et al. 2004. Br J Pharmacol. 142: 1332-42. PMID: 15265808
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB-215505, 5 mg | sc-253540 | 5 mg | $439.00 |