Molecular structure of SB 203580 (hydrochloride), CAS Number: 869185-85-3
SB 203580 (hydrochloride) (CAS 869185-85-3)
See product citations (2)
Application:
SB 203580 (hydrochloride) is an MAPK inhibitor
CAS Number:
869185-85-3
Purity:
≥98%
Molecular Weight:
413.9
Molecular Formula:
C21H16FN3OS HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SB 203580 (hydrochloride) is a pyridinyl imidazole inhibitor that displays a capacity to suppress proliferative activity on cytokine-activated lymphocytes. The same experiment has also shown that SB 203580 can inhibit the key cell cycle event of retinoblastoma protein phosphorylation in interleukin-2-stimulated T cells via inhibition of protein kinase B kinase. In addition, SB 203580, has been found to suppress the activation of mitogen-activated protein kinases (MAPKs). MAPKs have been found to regulate cell motility, differentiation, survival, and proliferation, therefore their inhibition can have a wide range of effects. We supply the SB203580 hydrochloride form.
SB 203580 (hydrochloride) (CAS 869185-85-3) References
- The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. | Lali, FV., et al. 2000. J Biol Chem. 275: 7395-402. PMID: 10702313
- ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. | Roux, PP. and Blenis, J. 2004. Microbiol Mol Biol Rev. 68: 320-44. PMID: 15187187
- Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. | Bhattacharyya, S., et al. 2007. Blood. 109: 4313-9. PMID: 17255352
- Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart. | Bell, JR., et al. 2008. Clin Exp Pharmacol Physiol. 35: 126-34. PMID: 17892505
- PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage. | Ma, Q., et al. 2011. Ann Neurol. 70: 920-31. PMID: 22190365
- Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection. | Börgeling, Y., et al. 2014. J Biol Chem. 289: 13-27. PMID: 24189062
- Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. | Lukjanenko, L., et al. 2016. Nat Med. 22: 897-905. PMID: 27376579
- Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats. | Jia, X., et al. 2021. J Neurochem. 158: 373-390. PMID: 33950542
- Protocol for the generation of blastocyst-like structures from mouse extended pluripotent stem cells. | Li, R. and Izpisua Belmonte, JC. 2021. STAR Protoc. 2: 100745. PMID: 34430918
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. | Cuenda, A., et al. 1995. FEBS Lett. 364: 229-33. PMID: 7750577
Inhibitor of:
MEK, PDK1, and Rb.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 203580 (hydrochloride), 5 mg | sc-204900 | 5 mg | $138.00 | |||
SB 203580 (hydrochloride), 10 mg | sc-204900A | 10 mg | $230.00 |