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SB 203580 (hydrochloride) is a pyridinyl imidazole inhibitor that displays a capacity to suppress proliferative activity on cytokine-activated lymphocytes. The same experiment has also shown that SB 203580 can inhibit the key cell cycle event of retinoblastoma protein phosphorylation in interleukin-2-stimulated T cells via inhibition of protein kinase B kinase. In addition, SB 203580, has been found to suppress the activation of mitogen-activated protein kinases (MAPKs). MAPKs have been found to regulate cell motility, differentiation, survival, and proliferation, therefore their inhibition can have a wide range of effects. We supply the SB203580 hydrochloride form.
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See how others have used SB 203580 (hydrochloride). Click on the entry to view the PubMed entry .
PMID: # 24988221 Hou, HH. et al. 2014. Autophagy. 10: 1509-21.
PMID: # 9013568 Foltz, I.N. et al. 1997. J. Biol. Chem. 272: 3296-3301.
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