SB 203580 (hydrochloride) CAS: 869185-85-3
MF: C21H16FN3OS HCl
MW: 413.9
An MAPK inhibitor.

SB 203580 (hydrochloride) (CAS 869185-85-3)

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Application: An MAPK inhibitor
CAS Number: 869185-85-3
Purity: ≥98%
Molecular Weight: 413.9
Molecular Formula: C21H16FN3OS HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SB 203580 (hydrochloride) is a pyridinyl imidazole inhibitor that displays a capacity to suppress proliferative activity on cytokine-activated lymphocytes. The same experiment has also shown that SB 203580 can inhibit the key cell cycle event of retinoblastoma protein phosphorylation in interleukin-2-stimulated T cells via inhibition of protein kinase B kinase. In addition, SB 203580, has been found to suppress the activation of mitogen-activated protein kinases (MAPKs). MAPKs have been found to regulate cell motility, differentiation, survival, and proliferation, therefore their inhibition can have a wide range of effects. We supply the SB203580 hydrochloride form.


References

1. Cuenda, A., et al. 1995. FEBS Lett. 364: 229-233. PMID: 7750577
2. Lali, F.V., et al. 2000. J. Biol. Chem. 275: 7395-7402. PMID: 10702313
3. Roux, P.P., et al. 2004. Microbiol. Mol. Biol. Rev. 68: 320-344. PMID: 15187187

Physical State :
Solid
Solubility :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), 1:10 solution of ethanol:PBS(pH 7.2) (~0.1 mg/ml), and water (25 mM).
Storage :
Store at 4° C
Boiling Point :
632.7° C at 760 mmHg (Predicted)
IC50 :
p38 MAPK: IC50 = 0.6 µM (heat-shocked HeLa cells and osmotically stressed PC12 cells); Prevent the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1: IC50 = 3-5 µM; SAPK2a/p38: IC50 = 50 nM; SAPK2b/p38β2: IC50 = 500 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UT3967600
MDL Number :
MFCD01862622
SMILES :
Fc1ccc(cc1)c1[nH]c(nc1c1ccncc1)c1ccc(cc1)S(=O)CCl

Download SDS (MSDS)

Certificate of Analysis

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SB 203580 (hydrochloride)  Product Citations

See how others have used SB 203580 (hydrochloride). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24988221  Hou, HH. et al. 2014. Autophagy. 10: 1509-21.

PMID: # 9013568  Foltz, I.N. et al. 1997. J. Biol. Chem. 272: 3296-3301.

Citations 1 to 2 of 2 total
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