SB 203580 (hydrochloride) CAS: 869185-85-3
MW: 413.9
An MAPK inhibitor.

SB 203580 (hydrochloride) (CAS 869185-85-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 152ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An MAPK inhibitor
CAS Number: 869185-85-3
Purity: ≥98%
Molecular Weight: 413.9
Molecular Formula: C21H16FN3OS HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SB 203580 (hydrochloride) is a pyridinyl imidazole inhibitor that displays a capacity to suppress proliferative activity on cytokine-activated lymphocytes. The same experiment has also shown that SB 203580 can inhibit the key cell cycle event of retinoblastoma protein phosphorylation in interleukin-2-stimulated T cells via inhibition of protein kinase B kinase. In addition, SB 203580, has been found to suppress the activation of mitogen-activated protein kinases (MAPKs). MAPKs have been found to regulate cell motility, differentiation, survival, and proliferation, therefore their inhibition can have a wide range of effects. We supply the SB203580 hydrochloride form.


1. Cuenda, A., et al. 1995. FEBS Lett. 364: 229-233. PMID: 7750577
2. Lali, F.V., et al. 2000. J. Biol. Chem. 275: 7395-7402. PMID: 10702313
3. Roux, P.P., et al. 2004. Microbiol. Mol. Biol. Rev. 68: 320-344. PMID: 15187187

Physical State :
Solubility :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), 1:10 solution of ethanol:PBS(pH 7.2) (~0.1 mg/ml), and water (25 mM).
Storage :
Store at 4° C
Boiling Point :
632.7° C at 760 mmHg (Predicted)
IC50 :
p38 MAPK: IC50 = 0.6 µM (heat-shocked HeLa cells and osmotically stressed PC12 cells); Prevent the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1: IC50 = 3-5 µM; SAPK2a/p38: IC50 = 50 nM; SAPK2b/p38β2: IC50 = 500 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

SB 203580 (hydrochloride)  Product Citations

See how others have used SB 203580 (hydrochloride). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24988221  Hou, HH. et al. 2014. Autophagy. 10: 1509-21.

PMID: # 9013568  Foltz, I.N. et al. 1997. J. Biol. Chem. 272: 3296-3301.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 96ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.