Molecular structure of SB 202190, CAS Number: 152121-30-7
SB 202190 (CAS 152121-30-7)
See product citations (45)
Alternate Names:
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Application:
SB 202190 is an inhibitor of the isoforms p38α and p38β
CAS Number:
152121-30-7
Purity:
≥98%
Molecular Weight:
331.34
Molecular Formula:
C20H14FN3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. The compound inhibits the isoforms p38alpha and p38beta. SB 202190 has displayed the ability to activate CPP32-like caspases and induce apoptosis. Research demonstrates that when one residue of ERK2, a related p38 not inhibited by pyridinyl imidazoles, is changed it allows SB 202190 to bind. Studies have revealed that SB 202190 can improve leukemia cell growth by activating MEK/MAPK, as well as phosphorylate and activate MLK3.
SB 202190 (CAS 152121-30-7) References
- Development of a p38 Kinase Binding Assay for High Throughput Screening. | Warrior, U., et al. 1999. J Biomol Screen. 4: 129-135. PMID: 10838421
- Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism. | Muniyappa, H. and Das, KC. 2008. Cell Signal. 20: 675-83. PMID: 18222647
- The p38 pathway inhibitor SB202190 activates MEK/MAPK to stimulate the growth of leukemia cells. | Hirosawa, M., et al. 2009. Leuk Res. 33: 693-9. PMID: 18995898
- Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. | Shanware, NP., et al. 2009. BMB Rep. 42: 142-7. PMID: 19336000
- Inhibition of nuclear factor-kappaB and p38 mitogen-activated protein kinase does not always have adverse effects on wound healing. | O'Sullivan, A., et al. 2010. Surg Infect (Larchmt). 11: 7-11. PMID: 19656014
- ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers. | Samak, G., et al. 2011. Am J Physiol Gastrointest Liver Physiol. 301: G50-9. PMID: 21474650
- Alpha1-adrenoceptor signaling in the human prostate involves regulation of p38 mitogen-activated protein kinase. | Strittmatter, F., et al. 2011. Urology. 78: 969.e7-13. PMID: 21982020
- Lipopolysaccharide-induced stem cell factor messenger RNA expression and production in odontoblast-like cells. | Oliveira, SH. and Santos, VA. 2012. J Endod. 38: 623-7. PMID: 22515890
- A p38 MAPK inhibitor improves outcome after glaucoma filtration surgery. | Nassar, K., et al. 2015. J Glaucoma. 24: 165-78. PMID: 25493622
- Computational Drug Target Screening through Protein Interaction Profiles. | Vilar, S., et al. 2016. Sci Rep. 6: 36969. PMID: 27845365
- Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). | Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
- Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase. | Nemoto, S., et al. 1998. J Biol Chem. 273: 16415-20. PMID: 9632706
- A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. | Fox, T., et al. 1998. Protein Sci. 7: 2249-55. PMID: 9827991
Inhibitor of:
β-defensin 21, β-defensin 22, β-defensin 26, β-defensin 43, β-defensin 50, β-defensin 8, 1010001N08Rik, 1190002F15Rik, 1190003J15Rik, 1190028D05Rik, 1200009I06Rik, 2700078E11Rik, 2810002I04Rik, 2810002N01Rik, 2810022L02Rik, 2810422J05Rik, Abp β, ACAM, ACTR-I, AMBRA1, ANKLE2, BC030336, BC055324, BC057079, BPLP, C-TAK1L, C030014O09Rik, C030017K20Rik, C030019I05Rik, C030030A07Rik, C030034I22Rik, C130039O16Rik, C130050O18Rik, C130079G13Rik, C19orf18, C230078M08Rik, C2orf70, C2orf79, C3orf1_4930455C21Rik, C6orf165, C6orf191, CLP36, cryptdin 5, Cypt6, Dppa1, Ear11, EDG-3, EG626575, Enzyme, FGF-1, fish, GCET2, GIPC2, GnRHR2, GPR17, GRIP-1, HIVEP1, Hog1, HPA2b, Hrs, HSH2, IFIT1, IFLTD1, IFN-γRα, IQCG, IRS-4, KIAA0226, Langerin, LILRC1, LOC100041356, LOC100041450, LOC728677, LOC730188, MA3, MEK-3, Mkk2, MPK-1, MYL1, myocilin, Myosin-neonatal, NDOR1, NFAT5, Nkx-6.1, nucleoporin p62, OBP-B, Olfr1038, Olfr1046, Olfr372, Olfr71, Olfr711, Olfr748, Olfr749, Olfr761, Olfr763, Olfr774, Olfr830, Olfr832, Olfr834, Olfr90, Olr1014, Olr542, Olr63, OR4D11, OTTMUSG00000011270, OTTMUSG00000011272, OTTMUSG00000011273, p38 alpha, Pbs2, Pellino 1, PGRMC1, Phocein, PHOSPHO2, PIWIL2, PLEKHM2, Polycystin-L, Ppapdc1a, PRRT1, PSG4, RIM-BP3C, RIPK, SBZF3, SCO1, Ser/Thr Protein Kinase, SFI1, SGK2, SLA2, Slac2-b, SLTM, SRP72, STAP-2, T1R2, TAJ-β, TAO2, TBRG4, TBZF, TEPP, TPD52, Tra-1, UPIIIa, V1RI4, Vmn1r1, Vmn1r127, Vmn2r15, VMP1, VPS26, WDFY2, ZDHHC18, ZNF225, ZNF226, ZNF233, ZNF432, ZNF570, ZNF66, and ZNF761.Activator of:
1110059G10Rik, 2810405K02Rik, 3110062M04Rik, 4932417I16Rik, ANGEL1, ANKRD30B, BC018465, BC031441, C-TAK1L, C030039L03Rik, C1orf177, D3Ertd254e, DC-TM4F2, DDX41, EDARADD, EG432555, EG434219, EG546638, FAM171A2, FBXW9, KIF20A, KRAB4, LIF, LOC729264, MOBKL2C, NHLRC4, Olfr394, OTUD1, p38γ, PP2Cβ, Ppp4r1l, SCOCO, SLA2, SLC26A6, and TRIM8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 202190, 1 mg | sc-202334 | 1 mg | $31.00 | |||
SB 202190, 5 mg | sc-202334A | 5 mg | $128.00 | |||
SB 202190, 25 mg | sc-202334B | 25 mg | $454.00 |