Molecular structure of Sauchinone, CAS Number: 177931-17-8
Sauchinone (CAS 177931-17-8)
Application:
Sauchinone is a diastereomeric lignan with cytoprotective and anitoxidant activites
CAS Number:
177931-17-8
Molecular Weight:
356.4
Molecular Formula:
C20H20O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Sauchinone is a diastereomeric ligand with cytoprotective and antioxidant activities in cultured hepatocytes. Sauchinone is an inhibitor of LPS-inducible iNOS (NOS II), TNF-α and Cox-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Sauchinone also acts as a suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit and inhibits staurosporine-induced apoptosis. Sauchinone inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
Sauchinone (CAS 177931-17-8) References
S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000). S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000). A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003). H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003). B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003). K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) .Inhibitor of:
I kappa B-α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sauchinone, 1 mg | sc-222288 | 1 mg | $36.00 | |||
Sauchinone, 5 mg | sc-222288A | 5 mg | $192.00 |