Sauchinone is a diastereomeric ligand with cytoprotective and antioxidant activities in cultured hepatocytes. Sauchinone is an inhibitor of LPS-inducible iNOS (NOS II), TNF-α and Cox-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Sauchinone also acts as a suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit and inhibits staurosporine-induced apoptosis. Sauchinone inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
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