SAST124 Antibody (21): sc-52725
- SAST124 Antibody (21) is a mouse monoclonal IgG1 SAST124 antibody provided at 100 µg/ml
- raised against amino acids 618-1094 of SAST124 of rat origin
- recommended for detection of SAST124 of mouse and rat origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SAST124 Antibody (21). This work is in progress.
SAST124 Antibody (21) is a mouse monoclonal IgG1 antibody that detects SAST124 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-SAST124 antibody (21) is available as a non-conjugated format. Syntrophin-associated serine/threonine kinase-124 (SAST124) plays a crucial role in cellular signaling as a member of the microtubule-associated serine/threonine kinases family, functioning as a signaling molecule for Syntrophin. SAST124 is predominantly expressed in specific neuronal populations, including those in the subventricular zone, granule cells of the olfactory bulb, Islands of Calleja, hippocampal dentate gyrus, and cerebellum, where SAST124 localizes to the nucleus. Nuclear localization of SAST124 suggests a role in transcriptional regulation, essential for the development and maintenance of neuronal characteristics shared by these regions. Through facilitating the connection between the extracellular matrix and intracellular cytoskeleton via the dystrophin-associated protein complex, SAST124 contributes to the structural integrity and functionality of postsynaptic structures in both the neuromuscular junction and central nervous system.
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SAST124 Antibody (21) References:
- Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. | Lumeng, C., et al. 1999. Nat Neurosci. 2: 611-7. PMID: 10404183
- The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. | Ort, T., et al. 2000. Eur J Cell Biol. 79: 621-30. PMID: 11043403
- Sast124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. | Yano, R., et al. 2003. Neuroscience. 117: 373-81. PMID: 12614677
- Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. | Valiente, M., et al. 2005. J Biol Chem. 280: 28936-43. PMID: 15951562
- Differential association of syntrophin pairs with the dystrophin complex. | Peters, MF., et al. 1997. J Cell Biol. 138: 81-93. PMID: 9214383
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAST124 Antibody (21) | sc-52725 | 100 µg/ml | $322.00 |