SAS10 Antibody (2950C2a): sc-81639

SAS10 Antibody (2950C2a) is a mouse monoclonal IgG1 antibody that detects SAS10 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-SAS10 antibody (2950C2a) is available as a non-conjugated format. SAS10 protein, also known as UTP3 or CRLZ1 (charged amino acid-rich leucine zipper 1), is a crucial component of the small subunit (SSU) processome, which plays a vital role in ribosome biogenesis and is essential for the maturation of pre-18S rRNA. Located primarily in the nucleus, SAS10 is not only involved in ribosome assembly but also contributes to the structural integrity of silenced chromatin, highlighting its importance in gene regulation. SAS10 is the human homolog of the Saccharomyces cerevisiae Sas10 protein, and studies have shown that overexpression of Sas10 in yeast can disrupt gene silencing, suggesting a similar function in humans. Additionally, SAS10 is implicated in brain development, and upon DNA damage, undergoes phosphorylation by ATM or ATR, which may influence its role in cellular responses to stress. This multifaceted involvement in critical cellular processes makes SAS10 a significant target for research in gene regulation and cellular response mechanisms.

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SAS10 Antibody (2950C2a) References:

1. Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse.  |  Sakuma, T., et al. 2001. Mech Dev. 104: 151-4. PMID: 11404095
2. The small-subunit processome is a ribosome assembly intermediate.  |  Bernstein, KA., et al. 2004. Eukaryot Cell. 3: 1619-26. PMID: 15590835
3. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.  |  Bleichert, F., et al. 2006. Proc Natl Acad Sci U S A. 103: 9464-9. PMID: 16769905
4. The HSS3/4 enhancer of Crlz1-IgJ locus is another target of EBF in the pre-B cell stage of B cell development.  |  Kim, JY., et al. 2006. Immunol Lett. 107: 63-70. PMID: 16962668
5. Stage-specific expression of two neighboring Crlz1 and IgJ genes during B cell development is regulated by their chromatin accessibility and histone acetylation.  |  Lim, JH., et al. 2006. J Immunol. 177: 5420-9. PMID: 17015728
6. Sir- and silencer-independent disruption of silencing in Saccharomyces by Sas10p.  |  Kamakaka, RT. and Rine, J. 1998. Genetics. 149: 903-14. PMID: 9611201

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SAS10 Antibody (2950C2a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SAS10 Antibody (2950C2a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SAS10 Antibody (2950C2a) Specifications

Alternate Product Name: SAS10

Product Clone Name: 2950C2a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: SAS10

Epitope Species: human

Product Reactivity/Detection: SAS10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SAS10 Antibody (2950C2a): N/A