SARS NC Antibody (3851): sc-58192

SARS NC Antibody (3851) is a mouse monoclonal IgG2b antibody that detects SARS nucleocapsid protein (SARS NC) of SARS virus by western blotting (WB) and immunofluorescence (IF). Anti-SARS NC antibody (3851) plays a crucial role in understanding the function of SARS nucleocapsid protein, which is essential for the viral life cycle as SARS NC encapsulates viral RNA and is involved in the assembly of new virions. SARS NC′s ability to interact with various cellular factors is significant, as SARS NC enhances the binding of transcription factors to promoter sequences of c-Fos, ATF2, CREB-1, and FosB, all integral components of the AP-1 signaling pathway. The selective activation of this pathway by SARS NC suggests SARS NC may serve as a critical target for therapeutic interventions aimed at modulating viral replication and pathogenesis. The unique evolutionary background of SARS NC, which shows closer resemblance to avian coronaviruses rather than other mammalian coronaviruses, underscores SARS NC′s distinct functional characteristics and potential as a biomarker in SARS research.