Molecular structure of Sarpogrelate hydrochloride, CAS Number: 135159-51-2
Sarpogrelate hydrochloride (CAS 135159-51-2)
Alternate Names:
MCI 9042
Application:
Sarpogrelate hydrochloride is aselective SR-2A antagonist
CAS Number:
135159-51-2
Purity:
≥99%
Molecular Weight:
465.97
Molecular Formula:
C24H31NO6 HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Has been shown to display selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Also displays cardioprotective activity in vivo.
Sarpogrelate hydrochloride (CAS 135159-51-2) References
Rashid et al (2003) Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 73 193. Brasil et al (2002) Blockade of 5-HT(2A) receptors by sarpogrelate protects the heart against myocardial infarction in rats. J.Cardiovasc.Pharmacol.Ther. 7 53. Nishiyama (2009) Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur.J.Pharmacol. 614 122.Inhibitor of:
SR-2A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sarpogrelate hydrochloride, 10 mg | sc-296371 | 10 mg | $155.00 | |||
Sarpogrelate hydrochloride, 50 mg | sc-296371A | 50 mg | $660.00 |