Molecular structure of Saquinavir, Mesylate, CAS Number: 149845-06-7
Saquinavir, Mesylate (CAS 149845-06-7)
Alternate Names:
Fortovase; Invirase; Ro 31-8959
Application:
Saquinavir, Mesylate is A biochemical that may be used in cell signaling and immunology studies.
CAS Number:
149845-06-7
Purity:
≥98%
Molecular Weight:
766.95
Molecular Formula:
C39H54N6O8S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Saquinavir, Mesylate is a protease inhibitor that functions by binding to the active site of the HIV-1 protease enzyme. This binding prevents the cleavage of viral polyproteins, ultimately inhibiting the maturation of infectious HIV particles. By interfering with the protease enzyme, Saquinavir, Mesylate disrupts the viral replication cycle, leading to the production of non-infectious viral particles. Saquinavir, Mesylate′s mechanism of action involves targeting the viral protease enzyme. Saquinavir, Mesylate′s interaction with the protease enzyme disrupts the virus′s ability to replicate and produce new infectious particles, making it useful for studying the molecular mechanisms of HIV infection.
Saquinavir, Mesylate (CAS 149845-06-7) References
- Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). | Williams, GC., et al. 2002. Antimicrob Agents Chemother. 46: 3456-62. PMID: 12384350
- Saquinavir/Ritonavir: its evolution and current treatment role. | O'Brien, WA. 2006. AIDS Read. 16: 38-44; discussion 43. PMID: 16433471
- Safety and Efficacy in HIV-1-Infected Patients Treated with Ritonavir-Boosted Saquinavir Mesylate. | Knechten, H., et al. 2010. Arch Drug Inf. 3: 26-36. PMID: 20428230
- Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir. | Brouwers, J., et al. 2011. Antiviral Res. 91: 217-23. PMID: 21683096
- Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement. | Branham, ML., et al. 2012. Eur J Pharm Biopharm. 80: 194-202. PMID: 21906676
- Nanoemulsion-based intranasal drug delivery system of saquinavir mesylate for brain targeting. | Mahajan, HS., et al. 2014. Drug Deliv. 21: 148-54. PMID: 24128122
- Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation. | Hosny, KM. and Hassan, AH. 2014. Int J Pharm. 475: 191-7. PMID: 25178831
- Pharmacokinetics of Saquinavir Mesylate from Oral Self-Emulsifying Lipid-Based Delivery Systems. | Caon, T., et al. 2017. Eur J Drug Metab Pharmacokinet. 42: 135-141. PMID: 26846485
- Identification of degradation products of saquinavir mesylate by ultra-high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry and its application to quality control. | Thummar, M., et al. 2017. Rapid Commun Mass Spectrom. 31: 771-781. PMID: 28233930
- Development Of Saquinavir Mesylate Nanoemulsion-Loaded Transdermal Films: Two-Step Optimization Of Permeation Parameters, Characterization, And Ex Vivo And In Vivo Evaluation. | Hosny, KM. 2019. Int J Nanomedicine. 14: 8589-8601. PMID: 31802871
- Nanosized Cubosomal Thermogelling Dispersion Loaded with Saquinavir Mesylate to Improve Its Bioavailability: Preparation, Optimization, in vitro and in vivo Evaluation. | Hosny, KM. 2020. Int J Nanomedicine. 15: 5113-5129. PMID: 32764940
- Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers. | Alsenz, J., et al. 1998. Pharm Res. 15: 423-8. PMID: 9563072
- Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. | Kim, AE., et al. 1998. J Pharmacol Exp Ther. 286: 1439-45. PMID: 9732409
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Saquinavir, Mesylate, 10 mg | sc-208383 | 10 mg | $151.00 | |||
Saquinavir, Mesylate, 50 mg | sc-208383A | 50 mg | $333.00 |