Date published: 2026-4-4

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Saquayamycin B1 (CAS 99260-68-1)

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CAS Number:
99260-68-1
Purity:
≥98%
Molecular Weight:
596.6
Molecular Formula:
C31H32O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Saquayamycin B1 is a chemically intriguing member of the gilvocarcin group, known for its complex tetra-cyclic structure, usually derived from actinobacteria. This compound is particularly noted for its unique interaction with DNA, where it binds and, upon exposure to light, generates reactive oxygen species that cause DNA damage through the formation of adducts and strand breaks. This mechanism is pivotal in studies focused on the pathways of DNA damage and repair, offering insights into cellular responses to such stress without any therapeutic implications. In research settings, Saquayamycin B1 serves as a valuable tool to induce and study controlled DNA damage, helping to elucidate cellular repair mechanisms and the maintenance of genomic integrity, thereby deepening our understanding of molecular biology processes critical in maintaining cellular function and preventing mutagenesis.


Saquayamycin B1 (CAS 99260-68-1) References

  1. Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose.  |  Shaaban, KA., et al. 2012. J Nat Prod. 75: 1383-92. PMID: 22758660
  2. Two Cooperative Glycosyltransferases Are Responsible for the Sugar Diversity of Saquayamycins Isolated from Streptomyces sp. KY 40-1.  |  Salem, SM., et al. 2017. ACS Chem Biol. 12: 2529-2534. PMID: 28892347
  3. Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.  |  Bao, J., et al. 2018. J Antibiot (Tokyo). 71: 1018-1024. PMID: 30158647
  4. Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.  |  Qu, XY., et al. 2019. Mar Drugs. 17: PMID: 31075906
  5. Enhancement of angucycline production by combined UV mutagenesis and ribosome engineering and fermentation optimization in Streptomyces dengpaensis XZHG99T.  |  Li, Y., et al. 2021. Prep Biochem Biotechnol. 51: 173-182. PMID: 32815762
  6. Saquayamycin B1 Suppresses Proliferation, Invasion, and Migration by Inhibiting PI3K/AKT Signaling Pathway in Human Colorectal Cancer Cells.  |  Li, J., et al. 2022. Mar Drugs. 20: PMID: 36135759
  7. Targeted Isolation of N-Acetylcysteine-Containing Angucycline Derivatives from Streptomyces sp. MC16 and Their Antiproliferative Effects.  |  Kim, JG., et al. 2023. ACS Omega. 8: 38263-38271. PMID: 37867696
  8. Resistomycin Suppresses Prostate Cancer Cell Growth by Instigating Oxidative Stress, Mitochondrial Apoptosis, and Cell Cycle Arrest.  |  Aloufi, AS., et al. 2023. Molecules. 28: PMID: 38067602
  9. Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32.  |  Huang, H., et al. 2024. Mar Drugs. 22: PMID: 38248657
  10. nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale.  |  Nuñez Santiago, I., et al. 2024. Commun Chem. 7: 71. PMID: 38561415

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Saquayamycin B1, 500 µg

sc-364135
500 µg
$147.00

Saquayamycin B1, 1 mg

sc-364135A
1 mg
$227.00