Sapienic acid (CAS 17004-51-2)
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Sapienic acid, a mono-unsaturated fatty acid, is used in research studies due to its distinctive presence in sebum and its role in skin physiology. Researchers utilize sapienic acid in studies of lipid metabolism to understand how this fatty acid contributes to the skin′s lipid barrier and its antimicrobial properties, which are essential for maintaining skin health. In comparative biology, it is studied to discern the differences in skin lipid composition between humans and other mammals. Biochemists are interested in the enzymatic pathways that produce sapienic acid, which involves the desaturation of palmitic acid. Moreover, investigations into the lipid profiles of various skin conditions often measure sapienic acid levels to understand changes associated with skin health. This acid also serves as a starting point for synthesizing complex lipids in studies focused on the biochemical pathways of lipid synthesis and regulation.
Sapienic acid (CAS 17004-51-2) References
- Identification of Δ6-monounsaturated fatty acids in human hair and nail samples by gas-chromatography-mass-spectrometry using ionic-liquid coated capillary column. | Destaillats, F., et al. 2011. J Chromatogr A. 1218: 9384-9. PMID: 22119675
- Oral mucosal lipids are antibacterial against Porphyromonas gingivalis, induce ultrastructural damage, and alter bacterial lipid and protein compositions. | Fischer, CL., et al. 2013. Int J Oral Sci. 5: 130-40. PMID: 23867843
- Synthesis of novel lipoamino acid conjugates of sapienic acid and evaluation of their cytotoxicity activities. | Gopal, SC., et al. 2014. J Oleo Sci. 63: 717-22. PMID: 24919473
- Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways. | Fischer, CL., et al. 2016. J Bacteriol. 198: 157-67. PMID: 26483519
- Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation. | Park, HG., et al. 2016. Biochim Biophys Acta. 1861: 91-97. PMID: 26597785
- Quantification of Phytochemicals from Commercial Spirulina Products and Their Antioxidant Activities. | Al-Dhabi, NA. and Valan Arasu, M. 2016. Evid Based Complement Alternat Med. 2016: 7631864. PMID: 26933442
- Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells. | Astudillo, AM., et al. 2018. J Lipid Res. 59: 237-249. PMID: 29167413
- Hexadecenoic Fatty Acid Positional Isomers and De Novo PUFA Synthesis in Colon Cancer Cells. | Scanferlato, R., et al. 2019. Int J Mol Sci. 20: PMID: 30769921
- Oleate hydratase from Staphylococcus aureus protects against palmitoleic acid, the major antimicrobial fatty acid produced by mammalian skin. | Subramanian, C., et al. 2019. J Biol Chem. 294: 9285-9294. PMID: 31018965
- The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles. | Ferreri, C., et al. 2020. Cancers (Basel). 12: PMID: 32272739
- Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH. | Kuiack, RC., et al. 2020. J Bacteriol. 202: PMID: 32868405
- Characterization of grapevine fungal canker pathogens Fatty Acid Methyl Ester (FAME) profiles. | Wallis, CM., et al. 2022. Mycologia. 114: 203-213. PMID: 34890530
- Sapienic Acid Metabolism Influences Membrane Plasticity and Protein Signaling in Breast Cancer Cell Lines. | Küçüksayan, E., et al. 2022. Cells. 11: PMID: 35053341
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sapienic acid, 5 mg | sc-507078 | 5 mg | $493.00 |