Molecular structure of SANT-2, CAS Number: 329196-48-7
SANT-2 (CAS 329196-48-7)
Application:
SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG
CAS Number:
329196-48-7
Molecular Weight:
480.0
Molecular Formula:
C26H26ClN3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SANT-2 is a cell permeable antagonist of the Smoothened protein function and an inhibitor of SAG activity. SANT-2 has been used as al tool to study the Hedgehog (Hh) signalling pathway and to explore therapeutic uses for inhibitors of Smoothened. Because Hh over activation of has been observed among some cancers, SANT-2 and other Smoothened antagonists are being studied for their antitumor activities.
SANT-2 (CAS 329196-48-7) References
- Small molecule modulation of Smoothened activity. | Chen, JK., et al. 2002. Proc Natl Acad Sci U S A. 99: 14071-6. PMID: 12391318
- Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. | Feldmann, G., et al. 2008. Gut. 57: 1420-30. PMID: 18515410
- Evidence for allosteric interactions of antagonist binding to the smoothened receptor. | Rominger, CM., et al. 2009. J Pharmacol Exp Ther. 329: 995-1005. PMID: 19304771
- 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. | Miller-Moslin, K., et al. 2009. J Med Chem. 52: 3954-68. PMID: 19469545
- Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. | Büttner, A., et al. 2009. Bioorg Med Chem. 17: 4943-54. PMID: 19541490
- Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine. | Büttner, A., et al. 2012. Reprod Toxicol. 33: 254-63. PMID: 22265815
- Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. | Wang, Y., et al. 2012. ACS Chem Biol. 7: 1040-8. PMID: 22554036
- Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells. | Silva, LM., et al. 2018. Sci Rep. 8: 4985. PMID: 29563577
- Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition. | Sun, C., et al. 2021. RSC Adv. 11: 22820-22825. PMID: 35480433
Inhibitor of:
Smo.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SANT-2, 1 mg | sc-202801 | 1 mg | $140.00 |