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Salmeterol-d3 (CAS 497063-94-2)

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Alternate Names:
4-Hydroxy-α1[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol-d3; GR-33343X-d3
Application:
Salmeterol-d3 is a deuterated structural analog of albuterol
CAS Number:
497063-94-2
Molecular Weight:
418.58
Molecular Formula:
C25H34D3NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Salmeterol-d3 is a deuterated form of the longer-acting beta-adrenoceptor agonist salmeterol, where three hydrogen atoms are replaced with deuterium. This subtle alteration is significant for research applications, particularly when employing analytical techniques that require a high degree of precision. The incorporation of deuterium atoms in salmeterol-d3 makes it an ideal internal standard for mass spectrometry, allowing for more accurate quantification of the parent compound in biological samples due to the similar physicochemical properties but distinct mass difference. In addition, salmeterol-d3 is used in kinetic studies to understand the metabolism and distribution of salmeterol in the body by offering a stable isotopic label that can be traced throughout various metabolic processes. The deuterated version is essential in the detailed study of chemical-receptor interaction kinetics, as well, because it does not alter the biochemical profile of the compound while providing a detectable marker.


Salmeterol-d3 (CAS 497063-94-2) References

  1. The pharmacology of salmeterol.  |  Johnson, M. 1990. Lung. 168 Suppl: 115-9. PMID: 1974668
  2. Inhaled salmeterol and salbutamol in asthmatic patients. An evaluation of asthma symptoms and the possible development of tachyphylaxis.  |  Ullman, A., et al. 1990. Am Rev Respir Dis. 142: 571-5. PMID: 1975162
  3. Protection against allergen-induced asthma by salmeterol.  |  Twentyman, OP., et al. 1990. Lancet. 336: 1338-42. PMID: 1978163
  4. Simultaneous detection of residues of 25 β₂-agonists and 23 β-blockers in animal foods by high-performance liquid chromatography coupled with linear ion trap mass spectrometry.  |  Sai, F., et al. 2012. J Agric Food Chem. 60: 1898-905. PMID: 22329604
  5. Development of a sensitive method for simultaneous determination of fluticasone propionate and salmeterol in plasma samples by liquid chromatography-tandem mass spectrometry.  |  Silvestro, L., et al. 2012. Biomed Chromatogr. 26: 627-35. PMID: 22577660
  6. Simultaneous and confirmative detection of multi-residues of β₂-agonists and β-blockers in urine using LC-MS/MS/MS coupled with β-receptor molecular imprinted polymer SPE clean-up.  |  Fan, S., et al. 2013. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30: 2093-101. PMID: 24138591
  7. Pseudo template molecularly imprinted polymer for determination of 14 kind of β-agonists in animal urine by ultra-high-performance liquid chromatography-tandem mass spectrometry.  |  Suo, D., et al. 2017. J Chromatogr A. 1526: 23-30. PMID: 29050842
  8. Uncovering the regional localization of inhaled salmeterol retention in the lung.  |  Bäckström, E., et al. 2018. Drug Deliv. 25: 838-845. PMID: 29587546
  9. Effect of particle deposition density of dry powders on the results produced by an in vitro test system simulating dissolution- and absorption rates in the lungs.  |  Malmlöf, M., et al. 2019. Eur J Pharm Biopharm. 139: 213-223. PMID: 30862480
  10. Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging.  |  Hamm, GR., et al. 2020. J Aerosol Med Pulm Drug Deliv. 33: 43-53. PMID: 31364961
  11. Evaluation of β-agonists in blood meal: Validation of determination method and potential pathway for reentry into the environment.  |  Decheng, S., et al. 2020. J Chromatogr A. 1612: 460624. PMID: 31668866
  12. Airway Epithelial Lining Fluid and Plasma Pharmacokinetics of Inhaled Fluticasone Propionate and Salmeterol Xinafoate in Mechanically Ventilated Pigs.  |  Ewing, P., et al. 2021. J Aerosol Med Pulm Drug Deliv. 34: 231-241. PMID: 33216656
  13. Quick and high-throughput quantification of 22 β-agonists residues in animal-derived foods using enzymatic probe sonication.  |  Xiao, Z., et al. 2023. Food Chem. 408: 135262. PMID: 36571879

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Salmeterol-d3, 1 mg

sc-220089
1 mg
$420.00