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Salicylic Acid-d4 (CAS 78646-17-0)

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Alternate Names:
2-Hydroxybenzoic Acid-d4
Application:
Salicylic Acid-d4 is A deuterium labeled acetylsalicylic acid impurity B used in organic synthesis
CAS Number:
78646-17-0
Molecular Weight:
142.15
Molecular Formula:
C7H2D4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Salicylic Acid-d4 is a deuterated compound utilized in analytical and environmental research. As a stable isotope-labeled analog of salicylic acid, it is used as an internal standard for the precise quantification of salicylic acid in various sample matrices. The incorporation of deuterium atoms allows Salicylic Acid-d4 to be distinguished from the non-labeled compound in mass spectrometry, providing a methodological advantage by reducing the impact of mass interferences during detection. This is particularly beneficial in complex biological or environmental samples where accurate measurement is crucial. Researchers also employ Salicylic Acid-d4 in studies of biotransformation processes to trace the metabolic pathways of salicylic acid in organisms and to examine its environmental degradation. Such research is important for understanding the ecological impact of salicylic acid and related compounds, as well as their behavior in biological systems.


Salicylic Acid-d4 (CAS 78646-17-0) References

  1. Brief history of antipyretic therapy.  |  Mackowiak, PA. 2000. Clin Infect Dis. 31 Suppl 5: S154-6. PMID: 11113017
  2. Salicylic acid promotes seed germination under high salinity by modulating antioxidant activity in Arabidopsis.  |  Lee, S., et al. 2010. New Phytol. 188: 626-37. PMID: 20663063
  3. Screening and quantitative determination of twelve acidic and neutral pharmaceuticals in whole blood by liquid-liquid extraction and liquid chromatography-tandem mass spectrometry.  |  Simonsen, KW., et al. 2010. J Anal Toxicol. 34: 367-73. PMID: 20822673
  4. Validation of a method for the targeted analysis of 96 drugs in hair by UPLC-MS/MS.  |  Montesano, C., et al. 2014. J Pharm Biomed Anal. 88: 295-306. PMID: 24095804
  5. Effects of alcohol on human carboxylesterase drug metabolism.  |  Parker, RB., et al. 2015. Clin Pharmacokinet. 54: 627-38. PMID: 25511794
  6. Determination of pharmaceuticals in groundwater collected in five cemeteries' areas (Portugal).  |  Paíga, P. and Delerue-Matos, C. 2016. Sci Total Environ. 569-570: 16-22. PMID: 27328395
  7. Leptosperin is a distinct and detectable fluorophore in Leptospermum honeys.  |  Bong, J., et al. 2017. Food Chem. 214: 102-109. PMID: 27507454
  8. Analysis of Valproic Acid, Salicylic Acid and Ibuprofen in Whole Blood by GC-MS.  |  Stephenson, JB., et al. 2016. J Anal Toxicol. 40: 649-652. PMID: 27562965
  9. Pharmacokinetics and relative bioavailability of fixed-dose combination of clopidogrel and aspirin versus coadministration of individual formulations in healthy Korean men.  |  Choi, HK., et al. 2016. Drug Des Devel Ther. 10: 3493-3499. PMID: 27822013
  10. Development of a multi-residue method for the determination of human and veterinary pharmaceuticals and some of their metabolites in aqueous environmental matrices by SPE-UHPLC-MS/MS.  |  Paíga, P., et al. 2017. J Pharm Biomed Anal. 135: 75-86. PMID: 28012308
  11. Exploring natural variation for rice sheath blight resistance in Brachypodium distachyon.  |  Gill, US., et al. 2019. Plant Signal Behav. 14: 1546527. PMID: 30540521
  12. Bioavailability study of two 81-mg coated tablet formulations of acetylsalicylic acid in fed healthy subjects
.  |  Dolores, RC., et al. 2020. Int J Clin Pharmacol Ther. 58: 457-464. PMID: 32469305
  13. Responses of pea plants to multiple antagonists are mediated by order of attack and phytohormone crosstalk.  |  Basu, S., et al. 2021. Mol Ecol. 30: 4939-4948. PMID: 34347913
  14. Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows.  |  Fritz, BR., et al. 2022. J Dairy Sci. 105: 9869-9881. PMID: 36207189

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Salicylic Acid-d4, 5 mg

sc-212908
5 mg
$306.00

Salicylic Acid-d4, 50 mg

sc-212908A
50 mg
$408.00

Salicylic Acid-d4, 250 mg

sc-212908B
250 mg
$918.00

Salicylic Acid-d4, 1 g

sc-212908C
1 g
$2632.00

"I purchased the chemical (Lot No. C0325) and received the COA. However, I couldn't find the expiration date mentioned anywhere. Could you confirm the expiration date for me?"

Asked by: Yijin
Thank you for your question. The expiration date is March 2030.
Answered by: Sen Li
Date published: 2025-03-17
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Rated 5 out of 5 by from Various publications cite the use of SalicylicVarious publications cite the use of Salicylic Acid-d4, a labeled acetylsalicylic acid impurity B, as an organic acid in synthesis reactions. Studies suggest that Salicylic Acid-d4 acts as a phenolic phytohormone which controls plant growth, development, photosynthesis, transpiration, ion uptake, and transport. -SCBT Publication Review
Date published: 2015-03-13
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Salicylic Acid-d4 is rated 5.0 out of 5 by 1.
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