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Salicylic acid (CAS 69-72-7)

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Alternate Names:
2-hydroxybenzoic acid
Application:
Salicylic acid is an antiinflammatory inhibitor of cyclooxygenase activity
CAS Number:
69-72-7
Purity:
≥99%
Molecular Weight:
138.12
Molecular Formula:
C7H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Salicylic acid is a colorless, crystalline organic acid that functions as a key component in various chemical processes. It acts as a plant hormone, regulating growth and development, as well as playing a role in the plant′s response to stress, pathogens, and environmental changes. At the molecular level, salicylic acid functions as a signaling molecule, triggering specific pathways within the plant to activate defense mechanisms against pathogens and pests. It also modulates gene expression and protein activity, influencing the plant′s physiological responses. Salicylic acid′s mechanism of action involves its interaction with specific receptors and enzymes, leading to the activation of defense-related genes and the production of antimicrobial compounds. Function in experimental applications involves its use to study plant defense mechanisms and signaling pathways, providing insights into the molecular processes underlying plant immunity and stress responses.


Salicylic acid (CAS 69-72-7) References

  1. A central role of salicylic Acid in plant disease resistance.  |  Delaney, TP., et al. 1994. Science. 266: 1247-50. PMID: 17810266
  2. Salicylic Acid, a multifaceted hormone to combat disease.  |  Vlot, AC., et al. 2009. Annu Rev Phytopathol. 47: 177-206. PMID: 19400653
  3. Salicylic Acid Induction of Flavonoid Biosynthesis Pathways in Wheat Varies by Treatment.  |  Gondor, OK., et al. 2016. Front Plant Sci. 7: 1447. PMID: 27733857
  4. Efficacy of salicylic acid peel in dermatophytosis.  |  Saoji, V. and Madke, B. 2021. Indian J Dermatol Venereol Leprol. 87: 671-675. PMID: 31650983
  5. Exogenous Salicylic Acid Improves Phenolic Content and Antioxidant Activity in Table Grapes.  |  Blanch, GP., et al. 2020. Plant Foods Hum Nutr. 75: 177-183. PMID: 32086677
  6. Inhibitory mechanism of salicylic acid on polyphenol oxidase: A cooperation between acidification and binding effects.  |  Liao, T., et al. 2021. Food Chem. 348: 129100. PMID: 33515954
  7. Salicylic acid treatment mitigates chilling injury in peach fruit by regulation of sucrose metabolism and soluble sugar content.  |  Zhao, Y., et al. 2021. Food Chem. 358: 129867. PMID: 33979685
  8. Protective role of salicylic acid in gentamicin induced nephrotoxicity.  |  Fatimah, SN. and Usman, SM. 2021. Pak J Pharm Sci. 34: 869-874. PMID: 34602408
  9. Removal of salicylic acid by electrochemical processes using stainless steel and platinum anodes.  |  Köktaş, İY. and Gökkuş, Ö. 2022. Chemosphere. 293: 133566. PMID: 35016959
  10. Salicylic Acid Improves Growth and Physiological Attributes and Salt Tolerance Differentially in Two Bread Wheat Cultivars.  |  Abdi, N., et al. 2022. Plants (Basel). 11: PMID: 35890487
  11. Monitoring of salicylic acid content in human saliva and its relationship with plasma concentrations.  |  Cheng, S., et al. 2022. J Pharm Biomed Anal. 219: 114961. PMID: 35907319
  12. Polyfluorinated salicylic acid analogs do not interfere with siderophore biosynthesis.  |  Hegde, P., et al. 2023. Tuberculosis (Edinb). 140: 102346. PMID: 37119793
  13. Dose-dependent competitive block by topical acetylsalicylic and salicylic acid of low pH-induced cutaneous pain.  |  Steen, KH., et al. 1996. Pain. 64: 71-82. PMID: 8867248
  14. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid.  |  Mitchell, JA., et al. 1997. Mol Pharmacol. 51: 907-12. PMID: 9187256
  15. Mechanism of action of nonsteroidal anti-inflammatory drugs.  |  Vane, JR. and Botting, RM. 1998. Am J Med. 104: 2S-8S; discussion 21S-22S. PMID: 9572314

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Salicylic acid, 100 g

sc-203374
100 g
$46.00

Salicylic acid, 500 g

sc-203374A
500 g
$92.00

Salicylic acid, 1 kg

sc-203374B
1 kg
$117.00

Is this salicylic acid product from a natural source?

Asked by: Anonymous
This product is of Synthetic origin. Feel free to contact Technical Support for further assistance.
Answered by: Tech Service 1
Date published: 2020-11-16

Is this from a natural source? Is this extracted from willow bark

Asked by: Ross A Lee
Thank you for your question. This compound is of synthetic origin.
Answered by: Technical Support Europe
Date published: 2020-10-26

Is this salicylic acid USP grade?

Asked by: specialty
Thank you for your question. No, our chemicals are research grade. We can not provide USP grade material.
Answered by: Tech Service
Date published: 2019-11-15
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Rated 5 out of 5 by from Vlot et alVlot et al. (PubMed ID 19400653) found that Salicylic acid mediates defense signaling in plants. -SCBT Publication Review
Date published: 2015-03-10
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Salicylic acid is rated 5.0 out of 5 by 1.
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