Molecular structure of Salbutamol, CAS Number: 18559-94-9
Salbutamol (CAS 18559-94-9)
Alternate Names:
α-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-α,α1-diol
Application:
Salbutamol is a β2-adrenoceptor agonist
CAS Number:
18559-94-9
Purity:
≥96%
Molecular Weight:
239.31
Molecular Formula:
C13H21NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Salbutamol, also known as albuterol in some regions, is a short-acting β2-adrenergic receptor agonist with a pivotal role in research related to respiratory physiology and airway management. Its mechanism of action involves the selective stimulation of β2-adrenergic receptors, which leads to the activation of adenylate cyclase and a subsequent increase in the levels of cyclic adenosine monophosphate (cAMP) within cells. This cascade of intracellular events ultimately results in the relaxation of bronchial smooth muscle fibers and a decrease in the release of mediators of immediate hypersensitivity from cells, especially from mast cells. Given its rapid onset and efficacy in dilating airways, salbutamol is extensively utilized in scientific studies to understand the pathophysiology of asthma and other obstructive pulmonary disorders. Its ability to act specifically on β2 receptors with minimal β1-adrenergic receptor activity makes it useful in experimental models to explore the pharmacodynamics of bronchodilation and to develop novel therapeutic strategies targeting airway hyperresponsiveness and inflammation.
Salbutamol (CAS 18559-94-9) References
- Salbutamol disposition and dynamics in conscious rabbits: influence of the route of administration and of the dose. | Perreault, S., et al. 1992. J Pharmacokinet Biopharm. 20: 461-76. PMID: 1287197
- The effects of R-salbutamol on behavior and physiology of finishing pigs. | Marchant-Forde, JN., et al. 2008. J Anim Sci. 86: 3110-24. PMID: 18539829
- Binding characteristics of salbutamol with DNA by spectral methods. | Bi, S., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 111: 182-7. PMID: 23639734
- Salbutamol extraction from urine and its stability in different solutions: identification of methylation products and validation of a quantitative analytical method. | Garrido, BC., et al. 2013. Biomed Chromatogr. 27: 1630-8. PMID: 23801106
- A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants. | Flores, P., et al. 2016. Pediatr Pulmonol. 51: 418-25. PMID: 26334188
- Enhanced simultaneous detection of ractopamine and salbutamol--Via electrochemical-facial deposition of MnO2 nanoflowers onto 3D RGO/Ni foam templates. | Wang, MY., et al. 2016. Biosens Bioelectron. 78: 259-266. PMID: 26623510
- A novel aptasensor for electrochemical detection of ractopamine, clenbuterol, salbutamol, phenylethanolamine and procaterol. | Chen, D., et al. 2016. Biosens Bioelectron. 80: 525-531. PMID: 26890828
- Salbutamol in paediatrics: pharmacology, prescribing and controversies. | Andrzejowski, P. and Carroll, W. 2016. Arch Dis Child Educ Pract Ed. 101: 194-7. PMID: 27059284
- Gnaphaliin A and gnaphaliin B synergize the relaxant effect of salbutamol but not of ipratropium in guinea pig trachea. | Rodríguez-Ramos, F., et al. 2016. J Pharm Pharmacol. 68: 533-41. PMID: 27061296
- Salbutamol Residues in Plasma, Urine and Hair of Heifers After a Single Dose and Throughout. | Zhang, K., et al. 2016. J Anal Toxicol. 40: 454-9. PMID: 27165803
- Evidences for salbutamol metabolism by respiratory and liver cell lines. | Nakpheng, T., et al. 2017. Drug Metab Pharmacokinet. 32: 127-134. PMID: 28318879
- Residues of Salbutamol and Identification of Its Metabolites in Beef Cattle. | Zhang, K., et al. 2017. J Agric Food Chem. 65: 2867-2875. PMID: 28322048
- Quantitation of salbutamol using micro-volume blood sampling - applications to exacerbations of pediatric asthma. | Cordell, RL., et al. 2018. J Asthma. 55: 1205-1213. PMID: 29211599
- Determination of ractopamine and salbutamol in pig hair by liquid chromatography tandem mass spectrometry. | Chang, KC., et al. 2018. J Food Drug Anal. 26: 725-730. PMID: 29567243
Inhibitor of:
beta1-AR, GPR83, OR5K1, RSHL3, SFRS17B, SULT1A3, and VPAC2.Activator of:
β2-AR, δ-sarcoglycan, 1700034O15Rik, 1810020O05Rik, AKAP 13, AP1AR, ARHGAP20, ARHGAP4, ARHGAP9, ARRDC2, ATP9BL2, beta2-AR, C11orf70, CC10, CCDC105, CCDC153, CCDC60_Ccdc60, CCDC82, CCDC85C, CCDC91, CCDC97, CELSR3, CLCA1_Clac1, CLDND2, COPE, CREBL2, D54, dHAND, Duffy, ECRG4, EPCR, ETL, Factor I, FAM118B, FAM228B_A830093I24Rik, FAM40A, FBL20, FRG1B, Gα s, GH, GHRH-R, GPR-137, GPR-152, GPR149, GPR3, HARBI1, HSL, I-309, KBTBD3, KCTD20, KCTD21, KLHL26, L7RN6, LOC643037, LYAG, MACROD2, MBD3L5, MC5-R, MCH-2R, MCP-5, MIPU1, MPND, MS4A12, MS4A3, Nim1, NOL8, NPS, OCEL1, Odf3, Olfr1061, Olfr390, Olfr393, Olfr566, Olfr715, Olfr716, Olfr790, Olfr791, Olfr792, Olfr794, Olfr798, Olfr799, Olfr8, Olfr800, Olfr801, Olfr802, Olfr803, Olfr804, Olfr805, Olfr806, Olfr807, Olfr808, Olfr809, Olfr810, Olfr811, Olfr813, Olr1020, Olr104, Olr1059, Olr1061, OR10A5, OR4C3, OR4D9, OR4F17, OR4X1, OR56A4, OR5B12, OR8B12, OR8G5, OR9G1, OR9Q2, OTTMUSG00000004012, OTTMUSG00000004013, OTTMUSG00000004461, OTTMUSG00000004551, OTTMUSG00000004963, OVCH2, PAC4, PATJ, PDE7B, PRR9, R9AP, RGS1, SCGBL, SDF-2L1, SEC14L1, Selenoprotein W, sFlt-1, Skint9, SMN, SNX10, SP-B, taperin, TARC, TCP-10b, Tdpoz2, Tdpoz3, Tdpoz5, TDRD10, TDRD7, Tect1, Tenrl, TEX10, TEX16, TEX19.2, TIP20, TLR11, TMEM132A, TMEM86B, TMEM9B, TPSB3, V3R 2, V3R 8, VAT1, VPAC2, WDR19, WDR46, XLαs, ZDHHC2, and ZFPL1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Salbutamol, 25 mg | sc-253527 | 25 mg | $94.00 | |||
Salbutamol, 50 mg | sc-253527A | 50 mg | $141.00 |